Dissertation > Excellent graduate degree dissertation topics show

The Expression of NALP1 and ASC in Colorectal Cancer

Author: LuXuNing
Tutor: RenShuangYi
School: Dalian Medical University
Course: Surgery
Keywords: NALP1 ASC colorectal cancer
CLC: R735.34
Type: Master's thesis
Year: 2011
Downloads: 7
Quote: 0
Read: Download Dissertation

Abstract


Objective: PYD and CARD are two domains in NALP1 as well as ASC , cspase1 which leads to inflammatory reaction and apoptosis, could be activated by CARD and PYD-PYD interaction between NALP1 and ASC. The expression of NALP1 and ASC in colorectal cancer was studied by RT-PCR and Western-blot to see the correlation with age, gender, dukes stage and the position of the tumor, and their expression location in colorectal cancer were studied by immunohistochemistry.Methods:1.RT-PCR: to discuss if the age, sex, dukes stage and position of the tumor are correlated with the amount of expression of NALP1 and ASC mRNA in colorectal cancer.2.Western-blot: to discuss if the age, sex, dukes stage and position of the tumor are correlated with the amount of expression of NALP1 and ASC protein in colorectal cancer.3.Immunohistochemistry: the expression of NALP1 and ASC protein in colorectal cancer tissue.Results:1.RT-PCR: the expression of NALP1 and ASC mRNA are not correlated with the age, sex, dukes stage and position of the tumor.2.Western-blot: the expression of NALP1 and ASC protein are not correlated with the age, sex, dukes stage and position of the tumor.3.Immunohistochemistry: the expression ot NALP1 and ASC protein presented fine brown particles in cytoplasm of colorectal cancer.Conclusion: NALP1、ASC express in cytoplasm of colorectal cancer. The expression are not correlated with the age, sex, dukes stage and position of the tumor.

Related Dissertations

  1. Effects of the Therapeutic Communication System Intervention on the Illness Uncertainty of Preoperative Colorectal Cancer Patients,R473.73
  2. Combination of Cervical Cytology Detected High Risk Human Papillomavirus Results of Analysis of 2221 Cases,R737.33
  3. Protein Expressions of EGFR、K-ras、P53 and Ki-67 in Colorectal Cancer, Gastric Cancer and Esophageal Cancer,R735
  4. Fundamental Research of the Function of Angiogenesis Inhibitors to Colon Cancer Stem Cells in Mice and Analysis of Related Mechanism,R735.35
  5. The Expression and Clinical Significance of EpCAMhigh /CD44+ Colorectal Cancer Stem Cells and β-catenin in Colorectal Cancer,R735.34
  6. Effects of TGF-β1 and Sodium Butyrate on Human Colorectal Cancer Cell Line HCT-116 Proliferation,R735.34
  7. The Expression and Significance of CD24 mRNA in Colorectal Polyps,R735.34
  8. Expression of ERCC1, nm23-H1 in Colorectal Carcinoma and Its Clinical Significance,R735.34
  9. The Clinic Study of Comparison between Laparoscopic with Open Colonrectal Radical Surgery,R735.3
  10. Study on the Short-term Endpoints of Conventional Versus Laparoscopic-assisted Surgery in Patients with Colorectal Cancer,R735.3
  11. Clinical Study on the Expression of VEGF in Liver Metastases of Colorectal Cancer and Its Effect on Prognosis,R735.3
  12. S100A4 protein expression in colorectal cancer and its clinical significance,R735.3
  13. Perioperative immune-enhancing enteral nutrition on immune function in patients with colorectal cancer effects,R735.34
  14. Blueberries and active substances on the intestinal flora imbalance and colorectal Preliminary Studies,R735.3
  15. Galectin-3, MMP-2 and MMP-9 expression in colorectal carcinoma and their correlation,R735.3
  16. The Studies of Celecoxib Affecting Its Expression Profiles of microRNA Mechanisms on Human Colon Cancer Cell Line HT-29 in Vitro,R735.35
  17. Mechanism of Methylated CpG Sites of MLH1 Gene in Colorectal Cancer Cells,R735.34
  18. Association of Polymorphisms in Estrogen Receptors with the Risk of Colorectal Cancer,R735.34
  19. Study of the Expressions of CEA, CA19-9 in Blood and Prognosis of Colorectal Cancer,R735.3
  20. Colorectal Cancer Translational Medicine Information Base Construction and Application of exploration,R735.3

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms > Colorectal tumors
© 2012 www.DissertationTopic.Net  Mobile