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Study on Totally Bioresorbable Composites as Cardiovascular Stent Material

Author: HanYaRu
Tutor: LiSuMing
School: Fudan University
Course: Materials Science
Keywords: Polylactic acid Poly- trimethylene carbonate Biodegradable Mechanical Properties Composites
CLC: R318.08
Type: Master's thesis
Year: 2011
Downloads: 81
Quote: 0
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Abstract


Cardiovascular stents in percutaneous coronary intervention treatment because of its less destructive to the patient, you do not need surgery, etc. and get more and more applications. Traditional bare metal stents has excellent mechanical properties, but due to the permanent presence of intravascular cause vascular late inflammation such as restenosis and other issues, completely biodegradable stents because of its excellent biocompatibility and bio-degradable been more and more attention and study. As used herein the low toxicity of zinc lactate as catalyst, synthesized by ring-opening polymerization of different optically active lactide and trimethylene carbonate (TMC), several different monomer ratio (L-LA or DL-LA) copolymerization thereof. In the above copolymer as the matrix, the polyhydroxycarboxylic Titanium polylactic acid copolymer (PLGA) fibers to enhance phase preparation completely biodegradable composites. The preparation of composite materials to compensate for polylactide, trimethylene carbonate (PTMC-LLA) copolymer with traditional fully bio-degradable scaffold material - L-polylactic acid (PLLA) - compared to the decline of the mechanical properties showed. Enhanced phase fibers subjected to surface treatment using oxygen plasma sputtering method, the composite with the copolymer matrix phase, and then placed in two hours of heat treatment under 100 ° C vacuum environment. Nuclear magnetic resonance spectroscopy, differential scanning calorimetry (DSC), size exclusion chromatography test method, static tensile test and other methods of the resulting copolymer and its composite tested in simulated body environment degradation experiments in vitro and animal degradation in vivo experiments. After comparing different component of the copolymer and its tensile properties of the composite material, prepared by ions and heat treatment of the fiber composite material of a composite material made of fibers than without a surface treatment or the tensile properties of the matrix material having a significantly improved . The final composite material obtained with the most commonly used of the polylactic acid scaffolds have similar tensile strength, and has a faster degradation rate compared with the copolymer; This is because the degradation of PLGA fiber speed is faster than the copolymer, so the composite material in the body The degradation rate can be adjusted to a certain extent, is conducive to the stent in vivo degradation and a discharge. Degradation in vivo experiments show PTMC-LLA copolymer slower than the speed of degradation of the PLLA and PTMC-DLLA copolymer, which is conducive to maintaining its mechanical properties in order to ensure the mechanical properties of the degradation of the initial stent. Accordingly, as the substrate, from lactide and trimethylene carbonate copolymer lactide - lactide copolymer fibers to enhance the preparation of a composite material due to its good mechanical properties, excellent flexibility, a small degree of crystallinity and smaller degradation acidity, and adjustable rate of degradation, is expected to become the next generation of cardiovascular stent materials.

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CLC: > Medicine, health > Basic Medical > Medical science in general > Biomedical Engineering > General issues > Biomaterial
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