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Stearyl Alcohol Galactosidase Sorafenib Modified Liposomes and Targeting of Mouse Liver

Author: SunShengFeng
Tutor: GuoWeiYing
School: Liaoning Medical
Course: Pharmaceutical Analysis
Keywords: Stearyl alcohol Sorafenib Liposomes Galactosidase Liver targeting
CLC: R943
Type: Master's thesis
Year: 2011
Downloads: 45
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Abstract


The purpose of this paper, stearyl alcohol (SA) galactosidase synthesis , structure identification , separation and purification , as well as design optimization with its modified of sorafenib (ST) liposomes prescription the Preparation and mice liver targeting studies targeting index (TI) changes to explore the stearyl alcohol galactosidase as the oriented molecules on the mouse liver targeting . Methods In this experiment, stearyl alcohol as the basic skeleton of the oriented molecules , the synthesis of a series of reactions by the one end to one end of the galactose liposoluble stearyl alcohol amphiphilic galacto glycoside oriented molecules ( 18 -Gal ) , and its lipid was prepared insoluble one end inserted into the liposomal phospholipid bilayers and modified sorafenib liposome, and orthogonal design Optimization the modified liposomes prescription process , the drug encapsulation efficiency , particle size of the modified liposomes modified liposomes targeted index (TI) changes as the evaluation index , the evaluation of the modified liposomes the encapsulation efficiency of the drug , the particle size , the targeting of the impact. Results of the modified 18-Gal sorafenib liposome encapsulation (18-GalST-LP) was 65.85% , particle size (203 ± 11) nm about animal experiments measured liver targeting index ( TI) value of 4.745 , indicating that 18-GalSt-LP with hepatic tropism . Conclusion prescription optimization stearyl alcohol galactosidase modified sorafenib liposome modified higher rate of liposomes , uniform particle size , liver targeting , and experimental results of further liver target the isotropic therapy provides a theoretical basis .

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