Dissertation > Excellent graduate degree dissertation topics show

Effects of Brain Natriuretic Peptide and Urinary Aquaporin-2 in Essential Hypertension

Author: TangYanFang
Tutor: KuangXiBin
School: Nanhua University
Course: Internal Medicine
Keywords: Essential hypertension Brain natriuretic peptide 2 water channel protein
CLC: R544.1
Type: Master's thesis
Year: 2008
Downloads: 38
Quote: 0
Read: Download Dissertation

Abstract


Objective: The detection of essential hypertension ( EH ) patients and normal plasma brain natriuretic peptide ( BNP ) , the concentration of urine aquaporin -2 ( AQP2 ) to explore the BNP and AQP2 in the pathogenesis of essential hypertension provide a theoretical basis for the role of hypertension diagnosis, treatment . Methods: 147 patients essential hypertension , left ventricular hypertrophy ( LVH ) and left ventricular hypertrophy ( NLVH ) in accordance with the left ventricular mass index ( LVMI ) Each group was further divided according to blood pressure levels is divided into 1 , 2,3 hypertension three subgroups , the other choice of 30 healthy people as a control group , plasma BNP concentration detected by enzyme linked immunosorbent assay (ELISA) , indirect enzyme-linked immunosorbent assay ( indirect ELISA ) to detect urine AQP2 concentration , and mean arterial pressure ( MAP ) , the application of SPSS 13.0 version statistical software for all measured values ??for statistical analysis of the relationship between all levels in hypertensive patients the plasma BNP levels and urinary AQP2 concentration , MAP . Results : 1 LVH group patients and normal control group , over NLVH patients : plasma BNP ( P lt ; 0.01 ) , urinary AQP2 concentrations were higher ( P lt ; 0.01 ) , three subgroups of different blood pressure levels in plasma BNP urine AQP2 concentration higher than the control group ( P lt ; 0.05 ) , and the same blood pressure level NLVH group ( P lt ; 0.05 ) , and increased with elevated blood pressure levels ( P lt ; 0.05 ) ; urine AQP2 concentration , plasma BNP concentration , MAP between the each other was positively correlated ( P lt ; 0.05 ) . 2 NLVH patients and normal control group : plasma BNP concentrations ( P lt ; 0.05 ) , urinary AQP2 concentrations were higher ( P lt ; 0.05 ) subgroups of plasma BNP, urine AQP2 concentration than the normal group increased , but between these two indicators in the sub-group had no significant difference ( P gt ; 0.05 ) ; and urine AQP2 concentrations , plasma BNP concentration , MAP are paired with each other no correlation ( P gt ; 0.05 ) . Conclusion : 1.LVH group serum BNP levels higher than normal control group and NLVH of group , suggesting that the detection of BNP is conducive to the early diagnosis of LVH in patients with essential hypertension complicated ; 2 . LVH subgroup of patients plasma BNP concentration increased blood pressure higher and higher ; group 3.LVH patients plasma urine AQP2 concentration and blood pressure levels were positively correlated with BNP levels , prompted BNP may affect the expression of AQP2 through the interaction between the cell messenger molecule ; 4. the NLVH group urine AQP2 concentrations higher than the normal control group, no significant correlation between plasma BNP concentrations , blood pressure levels .

Related Dissertations

  1. Plasma Galectin-3 Levels and Its Prognostic Value in Patients with Heart Failure,R541.6
  2. Clinical Study on Relationship Among Syndrome Differentiation Clssified in Tcm,ambulatory Blood Pressure Monitoring and Transcranial Doppler in Essential Hypertension,R259
  3. Heterogeneity and Meta Analysis of the Essential Hypertension Risk Assessments,R544.1
  4. Effects of Telmisartan on hs-CRP and HMW-adiponectinin Patients with Essential Hypertension,R544.1
  5. Preliminary Study of Left Atrial Volume and Left Ventricular Volume Changes in Essential Hypertensive Elderly Patients,R544.1
  6. Effect of Telmisartan and Benazepril on the Activity of Endothelial Lipase and Levels of Adiponectin in Patients with Mild Essential Hypertension,R544.1
  7. Association of Genetic Polymorphism in Brain Natriuretic Peptide with Essential Hypertension in Hunan Han,R544.1
  8. Analysis of Relationship between the A-6G Polymorphism of the Promoter Region of Angiotensinogen Gene and Essential Hypertension in Bai Nation,R544.1
  9. Analysis of Etiology of In-patients with Hypertension from Grade AAA Hospital in Xinjiang,R544.1
  10. The Relationship between the Level of Homocysteine and Important Target Organs Damage in Essential Hypertension.,R544.1
  11. The Serum Concentration of Brain Natriuretic Peptide, Endothelin-1 Levels, Pulmonary Artery Pressure in Patients with Left Heart Failure,R541.6
  12. Adiponectin in Heart Failure with Normal Ejection Fraction,R541.6
  13. Brain Natriuretic Peptide Changes after Acute Myocardial Infarction,R542.22
  14. Chronic rheumatic heart disease patients with atrial fibrillation perioperative plasma ANP and BNP levels and the significance of,R654.2
  15. Elderly heart failure patients with serum adiponectin , BNP, TNF-α correlation and its clinical significance,R541.6
  16. Diagnostic Value of Plasma N-Terminal Pro-Brain Natriuretic Peptide Levels in Different Types of Heart Failure,R541.6
  17. The Interventional Effects of Xuezhikang and Pravastatin on Serum NO, ET, HS-CRP, IL-1 and TNF-α in Simple Essential Hypertensive Patients,R544.1
  18. Combined detection Cardiotrophin -1 and brain natriuretic peptide in the diagnosis of cardiac dyspnea value,R541.6
  19. Correlation between Angiotensinogen Gene M235T Polymorphism and Essential Hypertension in the Bai Nationality,R544.1
  20. Plasma Retinol Binding Protein 4 Level and Its Correlation in Patients with Essential Hypertension of Kazakans,R544.1
  21. Alcohol consumption on cardiac structure, function, and serum levels of oxidative stress factor,R541

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
© 2012 www.DissertationTopic.Net  Mobile