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Chinese Simiao Tang rat abdominal aortic aneurysm growth in mice

Author: ZhengQiaoZuo
Tutor: LvYanWei
School: Liaoning University of Traditional Chinese Medicine
Course: Surgery of Chinese Medicine
Keywords: Simiao soup Abdominal aortic aneurysm Immunohistochemistry In situ hybridization Matrix metalloproteinase-2
CLC: R285.5
Type: Master's thesis
Year: 2009
Downloads: 41
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Abstract


Objective: To study medicine Simiao decoction on experimental abdominal aortic aneurysm formation. Materials and Methods: 40 male and female Wistar rats establishment of abdominal aortic aneurysms elastase perfusion model , check randomized controlled table is divided into four groups ( n = 10 male and a female 5 ) : experimental ( Simiao soup ) groups, the experimental ( honeysuckle Angelica ) group and normal control group, model control group . Experiment ( Simiao soup ) group was given Simiao Tang decoction 3ml, experimental ( honeysuckle Angelica ) group and model control group were infusion of the same dose of honeysuckle Angelica decoction and saline . Rate calculation arteries dilate the artery wall and observe histological changes , the application of CD68 ( macrophage -specific antigen ) immunohistochemical staining 3 weeks after arterial wall elastic fiber damage , macrophage infiltration , using in situ hybridization expression of matrix metalloproteinase-2 . Results : 1. 3 weeks after perfusion experiments ( Simiao soup ) group arteries was 28.63% ± 6.52%, experiment ( honeysuckle Angelica ) group arteries was 82.62% ± 8.38%, the model control group arteries was 114.36% ± 6.23%, P <0.05. No expansion of the normal control group arteries . (2) 3 weeks after perfusion experiments ( Simiao soup ) set minimum arterial wall injury , CD68 protein found in the intima ; experiments ( honeysuckle Angelica ) group with less damage to the arterial wall , CD68 protein common in the artery wall membrane ; model control distribution of CD68 protein in the membrane and the outer membrane in the arterial wall , the most important arterial wall injury , all groups were significantly different (P <0.05). Three experiments ( Simiao soup ) and experimental ( honeysuckle Angelica ) group were seen MMP-2 mRNA -positive cells , but the scope is small compared with the model group , the latter darker , normal control group showed a negative expression . Conclusions : 1. Medicine Simiao soup can slow macrophages in rat abdominal aortic aneurysm formation infiltration , thus inhibiting the growth of abdominal aortic aneurysms . (2) Chinese medicine Simiao soup can reduce the expression of matrix metalloproteinase-2 thus reducing arterial wall tissue elastic fiber degradation , suppression of experimental abdominal aortic aneurysm growth.

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