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Stomach cancer worldwide is one of the highest incidence of cancer is the second most common cancer in China. Every year about 900,000 new cases of gastric cancer, while 70 million people died of stomach cancer. The overall 5-year survival rate of gastric cancer in about 20%, the incidence of male and female 1.5 to 2.5 times. The incidence of gastric cancer increases with age significantly increased the peak incidence age of 50 years to 80 years. Therefore, early examination, early diagnosis, early treatment is the key means of reducing cancer mortality. Currently rely mainly on endoscopic diagnosis of gastric cancer and through the endoscope biopsy specimens taken from pathological examination, however, and pathology relatively long time, which to some extent also increased medical costs. So looking for a more convenient and accurate way to check is also very important. Raman spectroscopy is one of the available optical technology, malignant tissues and cells are always from the beginning of their constituent molecules in tissues and cells in the malignant process, composed of a variety of biological cells, tissues, chemicals type, quantity, structural, conformational, and the presence status will be in some extent change, and vibrational spectroscopic methods due to the molecular level reflects the structure of matter and changes, which may by tracking tissue malignant induced molecular changes in a tumor early diagnosis new methods. At present, scholars of lung cancer, liver cancer, esophageal cancer, breast cancer and other aspects of the research carried out spectroscopy, also confirmed the cancerous tissue and normal tissue there are differences in the spectral performance, on this basis, we have cancer, precancerous lesions and chronic gastritis in Raman spectroscopy showed differences on to do further research. Objective: Raman spectroscopy for gastric cancer, precancerous lesions and chronic gastritis were detected, derived gastric cancer, precancerous lesions and chronic gastritis different features of Raman spectroscopy. Methods: gastric cancer, precancerous lesions and chronic gastritis tissue samples removed from the refrigerator after thawing at room temperature Raman spectra collected on the sample stage. He-Ne laser power of 1mW, scan time is 20S, the scanning range is 20-3000cm-1, resolution of the instrument is 1cm-1. Result: gastric tissue Raman spectra 483cm-1, 2447cm-1 Raman peak near apparent, and precancerous lesions and chronic gastritis no obvious Raman peaks, and the fluorescence intensity is lower than gastric cancer precancerous lesions and chronic gastritis. Conclusion: Raman spectroscopy can be achieved for the diagnosis of gastric cancer.
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