Dissertation > Excellent graduate degree dissertation topics show

Percutaneous Microwave Coagulation Therapy for Hepatocellular Carcinoma: Experimental and Clinical Study

Author: LinZhou
Tutor: YangWeiZhu
School: Fujian Medical
Course: Medical Imaging and Nuclear Medicine
Keywords: Hepatic carcinoma Microwave Solidification Chemoembolization
CLC: R735.7
Type: Master's thesis
Year: 2008
Downloads: 49
Quote: 0
Read: Download Dissertation

Abstract


Clarity of purpose MTC-3 multifunction microwave therapy treatment parameters; Compare hepatic artery ligation, local injection of anhydrous alcohol or hypotonic saline and other factors microwave coagulation necrosis range and provide the basis for clinical application; comparison hepatic artery chemoembolization (TACE) and percutaneous microwave coagulation therapy (PMCT PMCT combination of the two) and the TACE percutaneous ethanol injection (PEI), the treatment of liver cancer. Vitro liver line simply microwave coagulation experiments, power 50 W to 80 W, time 10 to 20 min, recording the microwave coagulation scope and morphology of the various parameters; isolated liver is divided into simple microwave coagulation group, local injection of anhydrous alcohol group and hypotonic saline, power 60 W, time 10 min, each group were compared microwave coagulation necrosis range difference; vivo mongrel dogs were divided into simple microwave coagulation group, hepatic artery ligation group and hepatic artery ligation anhydrous alcohol group, power 60 W, time of 6 min, compare each group the microwave coagulation necrosis range of difference. Small hepatocellular carcinoma in 40 cases, admission has divided into the TACE PMCT, and TACE PEI PMCT two groups, 20 patients in each power of (65 ± 8.59) w, (12.4 ± 3.70) min. The patients were followed up for 1 to 20 months, by imaging, liver function, and AFP, inspection, evaluation of its efficacy. The results of animal experiments: in vitro liver simple microwave coagulation necrosis (2.0 ± 0.25) cm × (3.5 ± 0.34) cm (5.0 ± 0.42) cm × (5.3 ± 0.34) cm, coagulation necrosis volume (7.34 ± 4.05 ) cm3 to (69.43 ± 11.78) cm3; microwave coagulation necrosis range from the Pig Liver simple microwave coagulation group, of hypotonic saline group and anhydrous alcohol group compared to the alcohol group, saline, followed by both than simply microwave coagulation group was significantly increased (P lt; 0.05); the simple microwave coagulation group of in vivo dog liver, hepatic artery ligation group and the hepatic artery ligation anhydrous alcohol group formed transverse diameter (1.26 ± 0.39) cm, (1.67 ± 0.32) cm , (2.10 ± 0.34) cm, longitudinal diameter (2.32 ± 0.54) cm, (3.21 ± 0.67) cm, (3.60 ± 0.69) cm, the latter coagulation necrosis compared with the previous two groups significantly increased (P lt; 0.05 ). Clinical research: TACE PEI the PMCT group AFP 10 cases negative, negative rate of 90.9% (10/11); 18 cases of complete coagulation necrosis, necrosis rate of 90.0% (18/20). TACE PMCT AFP 11 patients with negative, negative rate of 73.3% (11/15); 16 cases of complete coagulation necrosis, necrosis rate of 80.0% (16/20). Comparing the two groups, the difference was not statistically significant (P values ??were gt; 0.05) Conclusion 1. Solidification experiments in vitro liver microwave clear MTC-3 multi-functional microwave instrument experimental parameters to guide the clinical application of PMCT treatment of liver cancer. Through a variety of intervention factor experiment clear hepatic artery ligation anhydrous alcohol can significantly expand the the microwave coagulation necrosis range and provide the basis for clinical application. Select TACE PMCT, or TACE PEI PMCT combination treatment of small hepatocellular carcinoma, were able to achieve the desired effect.

Related Dissertations

  1. Coupled Calculation of the Solidification Paths of Ternary Eutectic Alloys Based on Thermo-Calc,TG111.4
  2. Process Optimization and Degradation Kinetics for Microwave Vacuum Drying of Different Traditional Chinese Medicine Extract,TQ461
  3. Synthesis and Seperation of 1,1’-binaphthol,O625.3
  4. Study of Microwave Assisted Incineration of Asphalt Flue Gas,X701
  5. The Study of Anode Catalyst Pd/C for Direct Formic Acid Fuel Cell,O643.36
  6. Curing Mechanism and Properties of Fluorenyl Epoxy Resin,TQ323.5
  7. Preparation of Essence and Residues Powder from Flammulina Velutipes and Evaluation of Their Physical-Chemical Properties,S646.15
  8. Study on the Synthesis of New Containing Pyrazole Ring Aminophosphonate and 1,4-DPHs Derivatives,O626
  9. Gelatin Sponge Particles Embolization of Hepatocellular Carcinoma after Regulatory T Cells and Its Significance,R735.7
  10. The Research on the Therapeutic Effect of Microwave Ablation (MA) Combined with Injection of 5-fluorourac in Mice Bearing CT26 Colon Carcinoma Xenogrsfts,R735.35
  11. Research on Mena Expression and Its Clinical Significance in Hepatic Carcinoma,R735.7
  12. Remifentanil and isoflurane on liver function in patients with hepatocellular carcinoma Comparison,R614
  13. Retinoic acid and matrine intervention rat hepatoma change process β-catenin, E-cadherin, MMP-7 dynamic changes,R735.7
  14. α- aminoalkyl phosphonates Green Synthesis of,O627.51
  15. Simulation of Huge Rectangular Ingot by Different Intensive Cooling,TG244.3
  16. Numerical Simulation in Directional Solidification of Steel Ingot and the Study of Insulation Effect by Hollow Sidewall,TG111.4
  17. The Broussonetia papyrifera fiber structure and properties of microwave - assisted the degumming process parameters optimization,TS123
  18. Property Research on NiMnGa Magnetic Functional Materials,TG139.6
  19. Preparation of Unfired Bricks by Industry Sludge Solidified Cement and Analysis of Economy and Technique,X703
  20. Processing and Property Study of Mg2TiO4 -based Microwave Dielectric Ceramics,TN04
  21. Preparation of Fe3O4-MWCNTs Nanocomposites by Microwave Assisted Polyol Method and Their MRI Enhancement Properties,TB383.1

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
© 2012 www.DissertationTopic.Net  Mobile