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The Association between TLR3 c.1377, TLR9-1486, TLR9 2848 Gene Polymorphisms and Multiple Sclerosis

Author: JiXiaoZuo
Tutor: ZhouWenBin
School: Central South University
Course: Neurology
Keywords: Multiple sclerosis Toll-like receptor Single nucleotide polymorphisms
CLC: R744.51
Type: Master's thesis
Year: 2008
Downloads: 102
Quote: 0
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Abstract


Background and Purpose: multiple sclerosis (multiple sclerosis, MS) is a central nervous system white matter demyelinating autoimmune diseases, the cause is not yet entirely clear. Generally considered closely related to the pathogenesis of MS genetic, immunological and environmental factors. Toll-like receptor (the Toll likereceptor, TLR) 3, TLR9 as pathogen recognition receptors, in MS immunological pathogenesis play an important role, However, there is no molecular genetic susceptibility to MS. Of this study was to explore the southern Chinese Han population TLR3 and TLR9 single nucleotide polymorphism (Single Nucleotide Polymorphisms, SNPs) and MS genetic susceptibility, from the the gene molecular level to explore the pathogenesis of MS may, gene diagnosis of MS and treatment to provide a theoretical basis. Methods: A case-control study, 123 clinical and laboratory diagnosis of the southern Chinese Han MS patients and 126 patients enrolled race, age and sex-matched non autoimmune disease patients and healthy volunteers for the study peripheral venous blood extracted DNA using PCR-RFLP technology detection TLR3 and TLR9 gene polymorphism. Results: 1 in the southern Chinese Han population distribution of TLR3 c.1377 genotype frequencies were: CC 47.4%, CT 44.2%, TT 28.4%, allele frequencies were C69.5% and T 30.5% ; TLR9 -1486 genotype frequencies were: TT 39.0%, TC51.0%, CC 10.0%, allele frequencies were: 64.5%, C 35.5%; TLR92848 genotype frequencies were: GG 39.0%, GA 51.8%, AA 9.2%, allele frequencies were: G 64.9% and A 35.1%. 2, TLR3 c.1377 genotype, allele frequencies of the MS group and control group significant difference (P <0.05), T allele may reduce the prevalence of MS risk (OR = 0.532,95% CI = 0.322 -0.881, P = 0.014). , TLR9-1486 genotype and allele frequencies between the MS group and control group there was no significant difference in the distribution. TLR9 2848 A allele frequencies MS group than in the control group increased significant difference (MS 39.8% vs. Control 30.6%; P = 0.20). A allele carriers the ratio A ~~ - carriers of disease risk was significantly higher (OR = 1.837, CI = 1.096-3.080; P = 0.020). 5, correlation analysis found no TLR3 c.1377 TLR9-1486, TLR9 2848 combined effects. 6, TLR9-1486, TLR9 2848 is in linkage disequilibrium. Haplotype analysis of haplotype frequency distribution was no significant difference between the MS group and control group. Conclusion: 1.TLR3 c.1377 genotype frequency of allele frequencies and TLR9 2848 allele frequency and the southern Chinese Han population MS pathogenesis, two loci may MS susceptibility genes or susceptibility genes relative chain. 2.TLR9-1486 polymorphism and the southern Chinese Han population MS onset was no significant correlation.

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CLC: > Medicine, health > Neurology and psychiatry > Neurology > Spinal cord disease > Demyelinating disease > Multiple sclerosis
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