Dissertation > Excellent graduate degree dissertation topics show

The Value of Cystatin C in Detecting the Early Damage of Graft Function after Renal Transplantation

Author: ZhouShiMing
Tutor: TianJun
School: Shandong University
Course: Blood purification , kidney transplant
Keywords: Kidney transplant Renal Cystatin C Serum creatinine Glomerular filtration rate
CLC: R699
Type: Master's thesis
Year: 2008
Downloads: 32
Quote: 0
Read: Download Dissertation

Abstract


Objective: 1. Find a new indicator for the detection of renal function after kidney transplantation, initially used in the detection of graft function after renal transplantation and explore the relationship of the level of graft function (glomerular filtration rate). 2. Explore cystatin C after cysteine ??protease inhibitors C, serum creatinine (Scr), blood urea nitrogen (BUN) the comparison of the indicators, as indicators of early renal damage assessment value. Methods: Retrospective analysis method, dynamic monitoring of serum creatinine in 70 cases of renal transplant patients within a month after surgery, cysteine ??protease inhibitors C, Modification of Diet in Renal Disease equation (MDRD formula) the calculation of creatinine clearance . Subjects were divided into normal renal function group (A group, 31 cases, the GFR ≥ 90ml/min/1.73m), mildly impaired group (60 ≤ GFR lt; 90ml/min/m 2) group and renal function with moderate to severe impairment group (Group D, 4 cases, GFR lt; 60ml/min/m 2). Based on serum creatinine is normal or mild renal impairment creatinine group was divided into normal group (group B, 23 cases, SCR ≤ 133 micromol / L) and creatinine abnormal group (C group, 12 cases of SCR gt; 133μmol / L ). And compared with the control group (60 cases). Were drawn in each group of Cys C and a scatter plot of the relationship between SCR and CCR, and calculated the correlation coefficient (r). The use of immune-enhancing cystatin C level was measured by flow cytometry continuous detection of the CD4/CD8 ratio detected by ELISA immunosuppressant drug concentration to assess the state of the body's immune nephelometry. Blood biochemical analyzer determination of serum creatinine, blood urea nitrogen. Results: 1. Crowd cystatin C concentration is healthy and normal control (0.72 ± 0.13) mg / L. Serum creatinine concentration (50.48 ± 15.20) μmol / L. 2. Before transplantation cystatin C, serum creatinine, and blood urea nitrogen level was no significant difference (P gt; 0.05) 3 A group of cystatin C concentration (0.96 ± 0.10) mg / L. Group B cystatin C concentration of (1.37 ± 0.14) mg / L. Comparison with group A statistically significant difference (P lt; 0.05) 4. A serum creatinine concentration (90.51 ± 9.86) μmol / L. Group B serum creatinine concentration (105.27 ± 13.76) μmol / L. A group control was no significant difference (P gt; 0.05) 5. GFR in A, B, C and SCR, Cys C showed a straight line, where r = -0.7272 and -0.7439, -0.7072, -0.7543, -0.7430 and -0. 7669. Conclusion: Cys C concentration in renal transplant recipients renal injury early detection of great value. In patients with normal creatinine but CCR has reduced its concentration has significant changes, Cys C and creatinine clearance in patients with normal renal function and mild damage showed a linear correlation with a correlation coefficient compared with serum creatinine even better than serum creatinine. Cystatin C single diagnosis of renal injury, the more obvious changes, the performance is better than the other indicators. From decomposition in vivo metabolism, diet and other factors interfere, so it can be used in clinical routine testing indicators of postoperative renal function in renal transplantation. Peripheral blood Cystatin C detection assess the indicators of renal function as a non-invasive, the results show Cystatin C has high clinical value, can be simple, fast and accurate monitoring applied to a large number of transplant patients graft function .

Related Dissertations

  1. Based on the tutor clinical experience in medical treatment of chronic kidney disease proteinuria,R277.5
  2. The Yishenhuoxue methods for the treatment of kidney stones extracorporeal shock wave lithotripsy of renal injury after clinical studies,R277.5
  3. Application of Ascending-Descending Theory in Treatment of Chronic Renal Failure,R277.5
  4. The Investigation on the Renal Injury and Effects on Oxidative Stress of Guinea Pigs Induced by Trichloroethylene,R363
  5. Clinical Application Research of CT Urography in Mini-percutaneous Nephrolithotomy,R699
  6. The Influence of Dendritic Cell on Doxorubicin-induced Renal Fibrosis in the Rats,R692.5
  7. Study on Configuration, Function and Histopathology of Compensatory Kidney in Dog,S858.292
  8. Effect of Astragalus and Salvia’s Effective Components and Their Compatibility on JAK/STAT Pathway of Renal Fibrosis,R285.5
  9. Protective Effect of Ginsenoside Against Acute Renal Failure and Expression of ChAT-IR in the Lateral Magnocell of Hypothalamic Paraventricular Nuclei(PaLM),R285.5
  10. The Discussion of the Relationship between Plasma B-type Natriuretic Peptide and Ascites , Output of Urine Potassium and Natrium in Patients with Cirrhosis,R575.2
  11. Fucosylation Influences Extracellular Matrix Accumulation in Tgf-β-stimulated Hk-2 Cells,R692
  12. The Change of Serum Levels of the Zinc-alpha2-glycoprotein in Chronic Renal Failure and Its Relationship with Malnutrition,R692.5
  13. The Investigation and Research of QOL on Renal Transplantation Recipients and Living Donors,R699.2
  14. Clonal Origin of Multifocal Clear Cell Renal Cellcarcinoma Studied by Fluorescence in Situ Hybridization,R737.11
  15. Sorafenib Treatment of Advanced Kidney Cancer Efficacy and Safety Evaluation,R737.11
  16. Index Variation of Clinical Indicators in Patients with Intracerebral Hemorrhage (ICH) and Its Association with 15 STR Loci,R743.34
  17. 147 cases of maintenance hemodialysis patients nutritional status related factors,R692.5
  18. Application Evaluation normal serum creatinine glomerular filtration rate in patients with chronic heart failure, renal function,R541.61
  19. A Study of the Test of Kidney Fuceion by Observation of Ureter Jet with Coler Ultrasound,R692
  20. Expression and Clinical Significance of HIF-1α, HIF-3α in Renal Cell Carcinoma,R737.11
  21. An Experimental Study of Inhibition the Expression of Ppif Gene Reduce Renal Ischemia-reperfusion Injury in Rats,R363

CLC: > Medicine, health > Surgery > Urology ( urinary and reproductive system diseases) > Urinary tract and male reproductive system surgery
© 2012 www.DissertationTopic.Net  Mobile