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Expression and Significance of eIF4E, C-erbB-2 and FHIT in Pathological Scar

Author: ZhengZhiFang
Tutor: ZhuShiZe；WangChaoYang
School: Fujian Medical
Course: Surgery
Keywords: eIF4E C-erbB-2 FHIT Hypertrophic scars Keloid
CLC: R622
Type: Master's thesis
Year: 2008
Downloads: 44
Quote: 0
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Abstract


Objective: To study eIF4E, C-erbB-2 and FHIT in pathological scar tissue expression and relationship to explore their pathological scar formation and its mechanism . Methods: Immunohistochemical SP method combined with computer image analysis and pathology transcription polymerase chain reaction (RT-PCR) detection of normal skin , mature scars, hypertrophic scars and keloid tissue expression and distribution of eIF4E and analyzed statistically . Immunohistochemical SP method combined with computer pathological image analysis and detection of normal skin , mature scars, hypertrophic scars and keloid C-erbB-2 and FHIT expression and distribution and analyzed statistically . Results: 1 pathologic scar tissue eIF4E protein and mRNA expression increased , and normal skin , mature scar control group, the difference was statistically significant (P <0.005). Between keloid and hypertrophic scars , eIF4E protein and mRNA expression differences were not statistically significant (P> 0.05). 2 , pathologic scar tissue C-erbB-2 protein expression increased , and normal skin , mature scar control group, the difference was statistically significant (P <0.005). Between keloid and hypertrophic scars , C-erbB-2 protein expression was no significant difference (P> 0.05). 3 , pathologic scar tissue and normal skin FHIT protein expression , mature scar control group, the difference was not statistically significant (P> 0.05). 4, eIF4E and C-erbB-2 protein expression was significantly positive correlation exists (P <0.01). Conclusion : eIF4E and C-erbB-2 in both pathological scar tissue increased expression may be pathological scar formation plays an important role , there is a positive correlation between the two . In hypertrophic scar does not exist or reduce the loss of expression of FHIT , FHIT may be associated with abnormal proliferation of pathological scar irrelevant .

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CLC: > Medicine, health > Surgery > Plastic Surgery (repair surgery ) > Plastic surgery school
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