Dissertation > Excellent graduate degree dissertation topics show

Effects of Mesenchymal Stem Cells (MSCs) on Ischemia-Reperfusion Injury Following Rat Lung Transplantation

Author: LanHui
Tutor: HanBiao
School: Lanzhou University
Course: Department of Cardiothoracic Surgery
Keywords: Lung transplantation Ischemia-reperfusion injury mesenchymal stem cells,MSCs
CLC: R655.3
Type: Master's thesis
Year: 2008
Downloads: 49
Quote: 0
Read: Download Dissertation

Abstract


Objective To investigate effects of mesenchymal stem cells(MSCs)on short term of ischemia-reperfusion injury following rat lung transplantation.Methods Fourty health adult male Sprague-Dawley rats were randomly allocated to 2 groups with 8 rats in each group:lung transplantation group(Ⅰ)and the MSCs treatment group(Ⅱ).Single left lung transplantation with allografts were underwent and the MSCs was administered to the recipient rats through the pulmonary artery.After 6h reperfusion,the above of the lung graft was harvested to measure the activity of myeloperoxidase(MPO),the content of malondialdehyde (MDA)and the activity of erythrocuprein(SOD);The middle for measuring the biopsy specimens level of TNF-α,IL-1β,IL-8and the left for wet/dry weight ratio (W/D);The 2 groups were repeated for studying pathomorphology.Results The wet/dry weight ratio(W/D),the activity of myeloperoxidase (MPO),the activity of erythrocuprein(SOD)and the content of malondialdehyde (MDA)ofⅠgroup were higher than those ofⅡgroup(P＞0.05)after 6h reperfusion.The biopsy specimens level of TNF-α,IL-8 ofⅠgroup were higher than those ofⅡgroup(P＞0.05),but the IL-1βofⅠgroup were lower than those ofⅡgroup(P＞0.05).Inflammatory cell infiltration was not significantly reduced about the pathomorphology.Conclusion The MSCs doesnot protect the lung function against ischemia-reperfusion injury after transplantation within 6 hours.

Related Dissertations

  1. The Protective Effect of Rat Myocardial Ischemia/reperfusion Injury Following Bone Marrow Mesenchymal Stem Cell Pretransplantation for 1 Week,R542.22
  2. Effect of Nrf2-ARE Pathway on Isolated Rat Hearts Using Ischemia or Pinacidil Postconditioning,R96
  3. The Influence of Cold Self-bloodcardioplegia to MMP-2 Concentration for Infant with Cardiopulmulnary Bypass,R726.5
  4. The Relevance Research of Neuroglobin and Caspase-3 in the Hippocampus CA1 Regin in Global Cerebral Ischemia-reperfused Rats,R741
  5. Neuroprotective Mechanism of NBP Preconditioning in Cerebral Ischemia Reperfusion Injury on Sprague-Dawley Rats,R743.33
  6. Exogenous PCr anti- animal brain ischemia-reperfusion injury and brain-derived experimental study MODS,R965
  7. Post-treatment on ischemia-reperfusion injury in rat lung EGR-1 expression,R363
  8. VEGF-induced neuronal differentiation into mesenchymal stem cells migration research,R329
  9. Mechanisms of EGCG Attenuating Focal Cerebral Ischemia and Reperfusion Injury in Rats,R285.5
  10. An Experimental Study of Inhibition the Expression of Ppif Gene Reduce Renal Ischemia-reperfusion Injury in Rats,R363
  11. The Study on Monocarboxylate Transporter (MCT1) Expression Level of Rat Cardiac Myocardial Cells and Fibroblasts during Ischemia and Reperfusion,R614
  12. Lung Protection of Bradykinin Beta 2 Receptor Antagonist During Post-lung Transplantation with Ischemia/Reperfusion Injury,R655.3
  13. Co-releasing Molecule (CORM-2) Protect Against Renal Ischemia-reperfusion Injury in Mice,R699.2
  14. Oridonin preconditioning on rat hepatic resection autologous transplantation ischemia -reperfusion injury in rats and its mechanism,R657.3
  15. The Effects of Sufentanil Post-conditioning on hepatocellular Apoptosis Induced by Intestinal Ischemia-reperfusion in Rats,R965
  16. Effects of Sufentanil Post-conditioning on Acute Lung Injury Induced Ischemia-reperfusion in Rats,R965
  17. To Study the Effects of Low Potassium Dextran Solution Associated with Sodium Nitrade in the Model of the Dog Pulmonary Ischemia-reperfusion Injury,R965
  18. Effect of Willed Movement Therapy on the Expression of NT-3 and GAP-43 in Penumbra Area of Rats with Cerebral Ischemia Reperfusion,R743.3
  19. Mobilization of Bone Marrow Stem Cells by G-CSF Accelerates Renal Recovery after Ischemia-Reperfusion Injury in Mice,R692.5
  20. Effects of Remote Ischemic Preconditioning and Remote Ischemic Postconditioning on Myocardial Injury in Adults Undergoing Valve Replacement Surgery,R654.2
  21. Study on Myocardial Energy Metabolism and Mitochondrial Function Changes in I/R,R363

CLC: > Medicine, health > Surgery > Of surgery > Science in the chest outside the > Bronchus and lung
© 2012 www.DissertationTopic.Net  Mobile