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Preparation of Quinolones Molecularly Imprinted Polymer Microspheres and Study of Its Specific Adsorption Performance

Author: GaoYanBu
Tutor: FanJing
School: Henan Normal
Course: Analytical Chemistry
Keywords: Molecularly imprinted polymer microspheres Precipitation polymerization Gatifloxacin Levofloxacin Environmental analysis
CLC: O631.3
Type: Master's thesis
Year: 2010
Downloads: 73
Quote: 0
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Abstract


Molecular imprinting is a process for preparing the molecular recognition material having a specific recognition of the target molecule (template molecule) of emerging technologies. Molecular imprinted polymer its unique advantages, namely the specific recognition, as well as acid, alkali, organic solvent resistance, good thermal stability, long life and other advantages in many fields in recent years has been the rapid development of. The rapid development of the aquaculture industry in China, at the same time bring significant economic benefits to the people and the necessities of life, and also brought us a serious environmental problem. Especially the problem of antibiotic residues in the environment caused by the feed veterinary drugs exceeded increasingly a cause for concern. Environment and feed and food (meat, eggs, milk, etc.) in the high choice of antibiotic residues, the highly sensitive detection technology for environmental protection, food security, human health are of great significance. In this paper, molecular imprinting means prepared on the Quinolone antibiotics has specific selective molecularly imprinted polymer microspheres, and the performance of its specific recognition, expectations can be used in the widely used the gatifloxacin class antibiotic residues of veterinary drugs samples before processing, the main contents include: 1 simple introduction of molecular imprinting technique, summarized its application in the field of environmental analysis, and prospect of its development and the problems. 2, in order to add, gatifloxacin and levofloxacin as template molecule, methacrylic acid as a functional monomer, ethylene glycol dimethacrylate acrylate as crosslinker, azobisisobutyronitrile prepared by the precipitation polymerization method as initiator, two new molecularly imprinted polymer microspheres. And polymer microspheres were characterized using infrared spectroscopy and scanning electron microscopy, and pointed out that the difference in the structure and morphology of imprinted and non-imprinted microspheres. The microspheres have an average particle size of 100nm. Synthetic conditions detailed optimization to obtain the optimum ratio of the reaction reagent conditions. The use of ultraviolet spectroscopy to study the interaction between templates and monomers, initially speculated that the mechanism of action. By static adsorption experiments studied the adsorption properties of the polymer microspheres The results show that: the polymer to basically reach equilibrium within 40 minutes; adsorption isotherm measurements showed that the maximum adsorption capacity of the imprinted and non-imprinted polymer microspheres significant differences; Scatchard analysis of the binding properties of the polymer microspheres imprinted polymer microspheres in the concentration range studied memory in two classes of binding sites, rather than Imprinted Polymer Microspheres there is only one class of binding sites imprinted polymer microspheres prepared; the eight quinolones structural analogs selective adsorption experiments showed that good selective adsorption of such structural analogues; polymer microspheres can be recycled. 4 summarizes the results of this thesis, pointing out that the existing problems as well as a clear direction for future research.

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CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Polymer physics and physical chemistry of polymers > The chemical nature of polymers
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