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Amphiphilic Multi-arm Star Copolymer: Synthesis, Characterization and Application

Author: CaoPengFei
Tutor: ChenYu
School: Tianjin University
Course: Polymer Chemistry and Physics
Keywords: Amphiphilic Package and release Self-assembly Covalent bond stable Flower-shaped micelles
CLC: O631.3
Type: Master's thesis
Year: 2010
Downloads: 45
Quote: 0
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Abstract


In this thesis, arm star amphiphilic polymer polyethylenimine - block - poly ring caprolactone (PEI - b- PCL ) synthesis, modification , supramolecular self-assembly behavior and its use as a drug carrier the nature of the package and release . Hyperbranched polyethylene imine (PEI) having a multi - amino structure under the conditions as the catalyst with 2 - ethyl hexanoate , stannous to successfully triggered ε - cyclohexyl lactone ring-opening polymerization reaction, thereby to obtain a? - polycycloolefin caprolactone (PCL) for the shell, polyethylene imine (PEI) as the core of amphiphilic arm star polymer . Due to the polarity of the difference of the PCL outer arm with the PEI core , the resulting star polymer can be wrapped in a water - soluble guest molecule as a single molecule micelles . They object wrapped and release behavior of the PCL shell and PEI kernel modified adjusted. Esterified hydroxy terminated PCL shell capped PEI core the Quaternary Ammonium processing not only can effectively improve the the object wrapped capacity resulting single-molecule micelles can greatly slow down the resulting micelles are wrapped the rate of release of the guest molecules in the human body environment . Moreover, used in the esterification of a fatty acid carbon chain length and a counter ion of the quaternary ammonium salt polymer valence its parcels properties also have a certain impact . In addition, the arm star polymer PEI-b-PCL and the terminal hydroxy group is methyl acrylic modified after the product available on supramolecular self-assemble into micelles in aqueous solution . V50 initiator water-soluble initiator the polymerization reaction of the carbon-carbon double bond in the micelles obtained covalent bond stable kernel , surrounded with a large number of PCL inner arm and part of its rules of PEI crosslinked shell. This \Compared with the traditional structure of the micelle , this stable micelles non-polar guest molecules have a very high parcel capacity addition , compared with the starting micelle , this micelle form transition lost wrapped anionic object capacity, and inclusions having a cation guest molecule .

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CLC: > Mathematical sciences and chemical > Chemistry > Polymer chemistry ( polymer ) > Polymer physics and physical chemistry of polymers > The chemical nature of polymers
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