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Objective: To observe Xiaxi oral liquid on blood pressure in spontaneously hypertensive rats (SHR), serum angiotensin converting enzyme (ACE) activity, cardiac and abdominal aortic angiotensin Ⅱ -1 type receptor (AT 1, R) protein expression levels, and its role in protection of the heart, blood vessels and other target organs, and to further explore its mechanism. : 40 SHR blank group, the summer knee oral solution group, captopril group, irbesartan group 12-week-old SHR were randomly divided into 4 groups, each group of 10, and at the same time to select the 10-week-old. WKY rats served as a control group. ① tail artery pulse measurement experiments 2,4,6,8 weeks before and after the administration of the blood pressure values ??of each group of rats; take apical ② administered eight weeks after abdominal aortic tissue slices, HE staining , in the light microscope to observe the changes in its morphology; ③ The administration eight weeks after UV method for the determination of each group of serum ACE activity, immunohistochemistry (ICH) measured in each group rat cardiac and abdominal aortic AT 1 R protein expression. Results: ① the blood pressure of the treated rats were decreased to varying degrees, compared with SHR blank Xiaxi oral liquid group a significant difference (P <0.05) in the 4 weeks after administration, irbesartan group and Cato Plymouth group from 2 weeks after administration a significant antihypertensive effect (P <0.01); ② groups rat cardiac and vascular tissue was observed after HE staining, each treatment group compared with SHR damage in varying degrees of control group reduction; ③ the serum ACE activity: SHR blank group significantly higher than WKY group (P <0.01), summer knees oral solution group was significantly lower than the SHR the blank group (P <0.01), but still higher than the WKY group ( P <0.05), irbesartan group below the SHR the blank group (P <0.05), significantly higher than WKY group (P <0.01), the captopril group declined the most significant, with the WKY group showed no significant difference (P ④ rats myocardial and abdominal aortic AT , 1 average gray value of the R protein expression: WKY group was significantly higher than that of the SHR the blank group (P <0.01), summer knee Oral Solution> 0.05); group than in SHR blank control group (P <0.05), lower than the irbesartan group, captopril group was increased compared with SHR blank group but there was no significant difference (P> 0.05), irbesartan significantly high WKY group, in the the SHR blank group (P <0.01), no significant difference (P> 0.05). Conclusion: ① summer knee oral solution can be significantly reduced systolic blood pressure of SHR; 2 Xiaxi oral liquid has the protection of myocardial cells, protect the vascular endothelium, to prevent the proliferation of vascular smooth muscle cells and the role of wall thickening; ③ Xiaxi oral liquid can reduce the SHR serum ACE activity, has a mechanism of action similar to the ACEI; ④ summer knee oral solution can reduce SHR myocardium, vascular AT 1 |