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Objective: Magnetic resonance spectroscopic imaging (Proton Magnetic Resonance Spectroscopy to 1H-MRS) and diffusion-weighted imaging (Diffusion Weighted S Image DWI) technology joint research to explore 3.0T MRI voxel ~ 1H-MRS and DWI in common intracranial tumor characteristics analysis of application value. Methods: 32 patients with pathologically confirmed brain tumor patients (including grade Ⅰ ~ Ⅱ glioma eight cases, Ⅲ to Ⅳ grade gliomas eight cases, single metastatic tumor in seven cases of meningioma 9 cases), line magnetic the conventional resonance scanning and spectroscopic imaging and diffusion-weighted imaging. 1, the multi-voxel spectroscopic imaging: by ~ 1H-MRS imaging technique to observe the different ROIs concentration of various metabolites were measured in the tumor parenchyma, peritumoral area and reference areas NAA, Cho, Cr concentration, and calculation of NAA / Cho, NAA / Cr and Cho / Cr ratio, contrast tumors in different regions and at different levels, different types of tumors corresponding metabolite concentration and NAA / Cho, NAA / Cr and Cho / Cr ratio analysis of its clinical value differences between the tumor tissue and normal brain tissue, tumor and non-neoplastic lesions, as well as different types of tumor tissue, different levels of tumor tissue to evaluate voxel ~ 1H-MRS imaging in common intracranial tumor characteristics analysis . 2, diffusion-weighted imaging: DWI images and ADC maps to observe the change of the the different ROIs ADC value as a reference to the corresponding contralateral normal brain tissue were measured tumor parenchyma, peritumoral area and reference areas ADC value ADC value of the corresponding parts of the contrast tumors in different regions, different levels and types of tumors, to analyze the difference between distinguish between tumor tissue and normal brain tissue, different levels, different types of tumors, evaluation of diffusion-weighted imaging in common intracranial tumor value analysis. 3 the contrast ~ 1H-MRS and DWI changes in the value of the different regions in a variety of tumor characteristics, correlation analysis of tumor parenchyma Cho / Cr ratios and ADC values. Results: 1 MRS: (1) common intracranial tumor and normal brain tissue metabolite concentration differences: of NAA in the tumor tissue, the Cr signal the extent reduce or disappear, Cho signal increased to varying degrees, its metabolite ratios NAA / Cho , NAA / Cr decreased, Cho / Cr increased compared with normal reference area, a significant difference (P lt; 0.05). Feature (2) meningioma metabolite ratios: the meningioma tumor parenchyma NAA / Cr and NAA / Cho ratio was significantly lower than the high, low-grade gliomas and metastases, and Cho / Cr ratio was significantly higher than the other three , the difference was statistically significant (P lt; 0.05); meningioma peritumoral area NAA / Cr ratio is higher than the high-, low-grade gliomas and metastatic tumors, and the difference was statistically significant (P lt; 0.05), while the peritumoral Cho / Cr ratio is lower than the high-grade gliomas, the difference was statistically significant (P lt; 0.05). (3) high, each metabolite ratio differences between low-grade gliomas: the former tumor parenchyma NAA / Cr, NAA / Cho ratio is lower than the latter, and Cho / Cr ratios higher than the latter, and there are significant differences (P lt; 0.05); former peritumoral Cho / Cr ratios than the latter, both statistically significant difference (P lt; 0.05). (4) differences between metabolite ratios in the high-grade gliomas and solitary metastases: high-grade glioma tumor parenchyma NAA / Cr, NAA / Cho, the ratio is lower than solitary metastases, and the difference was statistically significant (P lt; 0.05); tumor parenchyma of both Cho / Cr ratio difference, and high-grade gliomas peritumoral edema Cho / Cr ratios than metastases, and a significant difference (P lt ; 0.05). , DWI: (1) common intracranial tumor and normal brain tissue ADC value differences: high, low-grade gliomas and solitary metastases of tumor parenchyma ADC values ??were higher than in normal brain tissue, a statistically significant difference (P lt; 0.05); the meningioma tumor parenchyma ADC values ??of normal brain tissue significant difference. (2) high the ADC value differences between low-grade gliomas: the former tumor parenchyma and peritumoral ADC value is lower than the latter, with a significant difference (P lt; 0.05). (3) the ADC value differences between high-grade gliomas and solitary metastases: ADC values ??of both tumor parenchyma significant difference, while the former peritumoral edema ADC value lower than that of the latter, and a statistically Differences between (P lt; 0.05). 3, the tumor parenchyma Cho / Cr ratios and ADC values ??of the correlation analysis: the values ??x, y scatter plot calculated the correlation coefficient r = -0.674 (P lt; 0.05). Conclusion: Multi-voxel ~ 1H-MRS can simultaneously in different regions of the tumor and normal reference region for spectral acquisition, the diagnosis of tumors, lesions range to make more accurate judgments. Combination of multi-voxel ~ 1H-MRS and DWI qualitative analysis and evaluation of the degree of malignancy of intracranial tumors, more more helpful information for the diagnosis and differential diagnosis of the tumor to help guide biopsy guidance surgery and formulation the radiotherapy program as well as monitoring treatment efficacy.
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