Dissertation > Excellent graduate degree dissertation topics show

Expression of Hypoxia Inducible Factor-1alpha and Its Correlation with Lymphangiogenesis in Lung Cancer

Author: ZhouSiJing
Tutor: LiuJian
School: Huazhong University of Science and Technology
Course: Geriatrics
Keywords: Lung cancer Lymphatic microvessel density Hypoxia-inducible factor -1α Vascular endothelial growth factor -C Transforming growth factor -α Lymph node metastasis
CLC: R734.2
Type: Master's thesis
Year: 2010
Downloads: 19
Quote: 0
Read: Download Dissertation

Abstract


Objective: To study lung cancer lymph node metastasis and hypoxia -inducible factor -1α (HIF-1α) relationship , and the mechanism of action of the latter may . Methods : Immunohistochemistry was used to detect 72 cases of cancer tissues , lung cancer and 20 cases of normal lung tissue hypoxia inducible factor - 1α ( HIF - 1α) , transforming growth factor -α (TGF-α) and vascular endothelial growth factor -C (VEGF-C) expression levels using D2-40 immunohistochemical method marked lung tissues ( including lung tissue , peritumoral tissue and normal lung tissue ) in the lymphatic and determination of lung tissue micro - lymphatic density (LMVD), correlation analysis , and three factor expression with the surrounding tissues , lymphatic microvessel density and cancer organizations lymphatic microvessel density and clinicopathological features of the relationship between the expression levels of the three factors statistical comparison . Results: D2-40 staining showed micro- lymphatic (LMV) mainly distributed in the surrounding tissues of the lung tissue , normal lung tissue and lung cancer tissue compared to few lymphatic vessels , lymphatic vessels in cancer tissues often be squeezed and deformed into the pipe for non-functional . A positive correlation between micro - lymphatic vessel density (LMVD) , level of lymph node metastasis of lung cancer with the surrounding tissues . HIF - 1α, TGF-α and VEGF-C protein expression levels in normal lung tissue was significantly lower than the lung tissue (both P lt ; 0.05) ; HIF -1α expression levels of TGF - alpha expression levels of the surrounding tissues LMVD and the expression of VEGF-C levels were positively correlated (r = 0.396,0.444 and 0.452 , both P lt ; were positively correlated (r = 0.05 ) , the expression levels of VEGF - C and TGF-α expression levels and cancer organizations LMVD respectively. 0.357 and 0.523 , all P lt; 0.05) . Conclusion: lung cancer lymph node metastasis in the lung tissue , HIF-1α expression significantly correlated . HIF-1α by upregulating the expression levels of TGF-α and VEGF-C in the lung tissue , and thus participate in the process of lymph node metastasis of lung cancer .

Related Dissertations

  1. The Clinical Research for the Effect of Iodine-125 Seeds Implanted in Advanced Bronchial Lung Cancer,R734.2
  2. The Expression of MMP-2、 VEGF and Ki-67 and Human Glioma Grade,R739.41
  3. Effects of 5-Aza-2-deoxycytidine on DNA Methylation and Expression of p16 and MGMT Gene in Lung Cancer Cell Line SPC-A-1,R734.2
  4. Methylation of p16 Gene in Plasma and Tissues from Non-small Cell Lung Cancer Patients, Demethylation and the Biological Behavior of Lung Cancer Cell and Transcription of p16 Gene,R734.2
  5. The Clinical Value of Detection of Serum TPS, CEA, CYFRA21-1, NSE for Diagnosis in Patients with Lung Cancer,R734.2
  6. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  7. The Research on Treatment of Lentivirus-mediated hVEGF-165 Gene Transferring Mesenchymal Stem Cells on Rat Hind Limb Ischemia,R329
  8. The Effect of RNA Interference-mediated ERCC1 Gene on the Chemo-treatment Sensitivity of NSCLC in Vitro,R734.2
  9. Non-small Cell Lung Cancer Analysis of 133 Cases of CVATS Lobectomy,R734.2
  10. Clinical Observation of Pemetrexed for Treating Advanced Non-small Cell Lung Cancer,R734.2
  11. Combined Detection of Tumor Markers in the Diagnosis and Treatment of Lung Cancer to Determine the Clinical Significance,R734.2
  12. Exploreing the Mechanism of Xieshifeiaifang Ii on Treating Lung Cancer with Pleura Effusion,R734.2
  13. BMP2 and VEGF165 Genes Transfected Rat Bone Marrow Mesechymal Stem Cells Simultaneity Expression,R329
  14. Expression of TNF-α, MMP-9 and VEGF in BALF of Rats with Emphysema and Their Mutual Relationship,R563.3
  15. Influence and Significance of MMP-2 and VEGF of Hemangioma Endothelial Cells in Vitro Culture by Propranolol,R739.5
  16. The Analysis of the M8000/3 Coder of the Lung Cancer Case in a Hospital Between 2006 to 2010,R734.2
  17. Expression of Chemokine Receptor CCR5 in Human Non-small-cell Lung Cancer,R734.2
  18. Influences of Cisplatin on Expressions of P-glycoprotein in the Resistance Cells of in Lung Cancer Xenografts in the Mice,R734.2
  19. Clinical Research on Detecing of the Combined Survivin mRNA with Cytokeratin 19(ck19) mRNA in Peripheral Blood of Non-small Cell Lung Cancer,R734.2
  20. Effect of Rh-Endostatin on the Expression of ERCC1 in Human Lung Adenocarcinoma A549 Cells,R734.2
  21. The Investigation of Relationship between Therapeutic Effect and Prognosis and Changes of Peripheral Blood Vascular Endothelial Growth Factor and Metallothionein in Patients with Advanced Lung Cancer,R734.2

CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
© 2012 www.DissertationTopic.Net  Mobile