Dissertation > Excellent graduate degree dissertation topics show

Valsartan adhesion molecule-1 expression in renal tubular epithelial cells

Author: GuoXiaoShan
Tutor: LiuJie；LiuTianFu
School: Shanxi Medical
Course: Endocrinology
Keywords: renal tubular epithetial cell diabetic nephropathy intercellular adhesion molecule-1 valsartan
CLC: R587.2
Type: Master's thesis
Year: 2005
Downloads: 55
Quote: 0
Read: Download Dissertation

Abstract


Objective To investigate the expression of intercellular adhesion molecule-1 in renal tubular epithelial cell of diabetic rats and the renoprotective effect of valsartan(val) Methods Diabetic rats were induced by streptozotocin(STZ) . Rats were randomly divided into four groups:normal control group, diabete group, val(10mg/kg·d by gavage)treatment group 1 and val(20mg/kg·d by gavage)treatment group 2. ICAM-1expresion were measured by immunohistological staining at 4,8 weeks of experiment. In addition , the relation between ICAM-1and urinary albumin excretion Results 24-hour urinary albumin excretion rate(P<0.01) Kidney weight/boby weight(p<0.01) and creatinine clearance in the group 2 were significantry lower than diabetic untreated rats. By immunohistological staining, there are a few positive expression of ICAM-1 in renal tubular cells,which became stronger in the diabetic rats as compared with nomal control rats(p<0.01).the expressionof ICAM-1in renal tubular cells was positively correlated with urinary albumin ( r=0.979,p<0.01 ) . Valsartan decreasere markably the expression of ICAM-1 in the renal tubular cells compared to diabetic rats(p<0.01) Conclusion ICAM-1 may play a role in the lesions of renal tubular epithetial cell,while valsartan may possess an effect on the protection of diabetic nephropathy may through decreasing the expression of ICAM-1 in the renal tubular cell.

Related Dissertations

  1. Low Dose of Spironolactone Reduces Oxidative Stress and Prevents the Development of Diabetic Nephropathy in Patients with Type 2 Diabetes Mellitus,R587.2
  2. Human adipose -derived mesenchymal stem cells to treat diabetic nephropathy rat studies,R692
  3. The Changes of T Lymphocyte Subsets and Costimulatory Molecules Before and After Shuxuetong Treatment in Type 2 Diabetes Subjects with Diabetic Kidney Disease,R692
  4. The Levels and Clinical Significance of Plasma ADMA and TGF-β1 in Patients with Type 2 Diabetic Nephropathy,R587.2
  5. The Study of Klotho Gene Expression Level in Debetics Nephometic Patients in Vivo,R692.9
  6. Correlation of type 2 diabetes serum TGF-β1 and PDGF-BB levels and urinary albumin excretion rate in patients with kidney disease,R587.2
  7. Modified Zhulingtang treatment of diabetic nephropathy Ⅳ stage clinical study,R692.9
  8. The Affection of Interleukin-1β and Leptin on Intercellular Adhesion Molecule-1 and Martrix Metalloproteinase 9 in the Human Endometrial Cells,R321
  9. The Significance and Level Changes of Urinary Albumin/creatinine Ratio and Serum Cystatin C on Type 2 Diabetic Nephropathy Patients,R587.2
  10. The Role of SIK1 in Type 2 Diabetic Nephropathy with Hypertension,R544.1
  11. The Expression of Angiopoietin-2 in Diabetic Nephropathy and Correlated with Proteinuria,R587.2
  12. Pentamethylquercetin on diabetic nephropathy in rats and its mechanism,R285.5
  13. Effect of Gypenosides on the Expression of Nephrin、VEGF in the Kidney of Diabetic Nephropathy Rats,R692.9
  14. The Prevention Effect of Hydration Therapy on Contrast-induced Nephropathy of Diabetic Nephropathy Patients,R692.9
  15. The Study on Relationship between Level of Serum Interleukin-6, Intercellular Adhension Molecue-1 and Premature Rupture of Fetal Membranceswith Sub-clinical Chorioammionitis,R714.433
  16. Study on the Absorption of PEPT1 Based Modified Valsartan Compounds,R96
  17. Effects of Lidocaine on Liver Injury Induced by Intestinal Ischemia-Reperfusion in Young Rats,R965
  18. Effect of Valsartan on Energy Metabolism of Myocardial Ischemia-reperfusion Injury in Rats,R965
  19. Analysis of the Relationship between the Expression of SARA and the Pathological Types and Clinical Phenotypes of Diabetic Nephropathy,R587.2
  20. The Curative Effect Comparison between Hemodialysis and Continuous Ambulatory Peritoneal Dialysis on End Stage Diabetic Nephropathy,R587.2
  21. Retrospective Analysis the Risk Factors of Hemodialysis for Diabetic Nephropathic Patients,R587.2

CLC: > Medicine, health > Internal Medicine > Endocrine diseases and metabolic diseases > Islet disease > Diabetic coma and other complications
© 2012 www.DissertationTopic.Net  Mobile