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[ Background and Purpose ] Lung cancer is one of the serious threat to human life and health disease , epidemiological data show that in the 1990s , lung cancer accounts for the death of China 's urban population , accounting for third place in the countryside . The main reason is found the majority of lung cancer patients have advanced the treatment of lung cancer is still surgery, radiotherapy , chemotherapy , side effects , and the overall 5-year survival rate of only 13% . The study showed that the incidence of lung cancer is mainly due to the activation of oncogenes and inactivation of tumor suppressor genes lead to the uncontrolled cell growth caused . Therefore , to explore the molecular basis of lung cancer prevention, diagnosis , and new ideas for the treatment of lung cancer is especially important from the genetic level to find . FHIT gene is a new tumor suppressor gene discovered in recent years , had a high frequency in a variety of tumors early , even in precancerous lesions of atypical hyperplasia stage occurs exception , and therefore is considered to be a useful clinical application potential the prevention, diagnosis and treatment of the target gene . But its mechanism of action , the role of path unclear relationship of FHIT gene and its expression in protein and proliferation / differentiation , apoptosis regulatory network of other important tumor-related genes ( such as P21 , P16, Rb, CDK , PCNA , etc.) are to be discussed . In this study, using immunohistochemical method study benign lung lesions and lung tissue of FHIT , P21 WAF / CIP , PCNA expression and its correlation to explore the role of FHIT in non-small cell lung cancer development gene for lung cancer diagnosis , treatment and prevention provide a theoretical basis . [ Materials and Methods ] experimental group is surgical resection and 80 cases of pathologically confirmed non- small cell lung cancer specimens , including 50 males and 30 females ; ages 20-79 years , mean age 59.25 ± 6.78 years , which is greater than or equal to 60 year-old patient
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