Dissertation > Excellent graduate degree dissertation topics show

Study on the Level of Serum S100-B Protein in Patients During CABG with Versus without Cardiopulmonary Bypass

Author: ZhangRuiXiang
Tutor: HongFeng
School: Jinan University
Course: Surgery
Keywords: Coronary Artery Bypass Grafting S100-B protein Minimally invasive Cardiopulmonary bypass Cerebral injury
CLC: R654.2
Type: Master's thesis
Year: 2005
Downloads: 22
Quote: 0
Read: Download Dissertation

Abstract


ObjectiveTo investigate the mutative law of the serum S100-B protein in patients undergone coronary artery bypass grafting(CABG) with cardiopulmonary bypass(CPB) and without CPB, compare the degree of cerebral injury in patients during CABG between the two different surgical manipulations, and probe into the factor working on the level of serum S100-B protein concentration.Methods30 patients were divided into two groups : general operation group of CABG with CPB (Group A) and minimally invasive operation group of that without CPB(Group B), and either group included 15 patients. The patients in Group A underwent the operation of CABG with CPB, and those in Group B did without CPB. 4ml blood of jugular vein was phlebotomized from every patient at the following 8 time points: pre-operation, post-anaesthesia, the time when the side-aortic forceps open, the end of operation, 2 hours after operation, 6 hours after operation, 12 hours after operation, and 24 hours after operation. The blood samples were centrifuged atthe speed of 3000rpm for 10 minutes and serum samples were saved in the special refrigerator(-70 ℃). The serum concentration of S100-B protein in the samples were measured with the measure of ELISA, and the times of Cardiopulmonary Bypass in Group A and the manipulative times on the heart in Group B were registered. All the data were analyzed using the software of SPSS10.0 for Windows.ResultsThe two groups had similar preoperative characteristics and there were no cases of deaths or prominent neurological complications in both groups. The level of serum S100-B protein increased markedly at the beginning of CPB, and the peak value was treble higher than that of the patients in Group B. The concentration of S100-B protein in serum increased only slightly during the CABG operation in the patients of Group B. The level of S100-B protein tended to be normal level in both groups 24 hours after operation. The level of S100-B protein during the operative process was not influenced by the anesthetic and the manipulation, but had notable relation with the time of cardiopulmonary bypass in Group A ( r=0.659, t=3.160, P =0.008) and the manipulative time on the heart in Group B ( r=0.584, t=2.190, P =0.022) .Conclusion1. The peek values of serum S100-B protein in patients of Group B is magnificently lower than that of Group B and the latter is treble times higher than the previous. It is can be concluded that The minimally invasive coronary artery bypass grafting without CPB can reduce the degree of cerebral damage and avoid functional disorder of the central nerve system because the physiological state in the operation is closer to the normal.2. The value of S100-B protein during the operative process was not influenced by the anesthetic and the manipulation, but had notable relation with the time of CPB inGroup A and the manipulative time on the heart in Group B. CPB and the manipulation on the heart may be the major factor to the cerebral damage during the operation.

Related Dissertations

  1. Clinical Comparative Study of 23-gauge Transconjunctival Sutureless Vitrectomy and Conventional 20-gauge Vitrectomy for Rhegmatogenoue Retinal Detachment,R779.6
  2. Aspirin Resistance after Off-pump Coronary Artery Bypass Grafting Surgery,R654.2
  3. Effects of Ulinastatin on Inflammatory Response to Cardiopulmonary Bypass in Cardiac Valve Replacement Surgery,R614
  4. The Clinical Study on the Protective Effects of Sodium Ferulate in Vascular Endothelial Function during Cardiopulmonary Bypass,R654.1
  5. Thoracosopic-assisted Esophagectomy for Esophageal Cancer: Three Patterns Comparison,R735.1
  6. Comparison of MIPO and Intramedullary Nail Fixation in the Treatment of Humeral Shaft Fractures,R687.3
  7. Comparison of the Myocardial Protection of Etomidate and Propofol in Patients with Open Heart Surgery During Cardiopulmonary Bypass.,R654.2
  8. Clinical Observation on the Lumbar Disc Herniation’s Treatment by Minimally Invasive Disc Surgery Dissolved Ozone and Massage,R244.1
  9. Effects of Insulin on Blood Glucose Control for Patients Undergoing Cardiac Valve Replacement with Cardiopulmonary Bypass,R654.2
  10. Comparative Studies of On-pump and Off-pump Coronary Artery Bypass Grafting,R654.2
  11. Perioperative Changes in Serum Concentrations of H-FABP IMA and cTnI in Patients Undergoing Coronary Artery Bypass Grafting,R654.2
  12. The Effects of Ulinastatin on Pulmonary Injury in Patients with Rheumatic Mitral Stenosis Undergoing Mitral Valve Replacement,R654.2
  13. The Treatmen of Distal Tibial Fractures with Posteromedial Plate and Bone-setting Manipulation: An Anatomical Research and Clinical Applied Study,R687.3
  14. Comparison of Clinical Efficacy about Minimally Insvasive Percutaneous Osteosynthesis and Traditional Surgery to Treat the Proximal Humeral Fractures,R687.3
  15. The Therapy of Lumbar Spondylolisthesis with PLIF Through Posterior Sole Small Incision of Mocroendoscopic Discectomy,R687.3
  16. The Clinical Significance of Dynamic Monitoring Arterial Blood Lactic Acid in Severe Patients during Perioperative Period of Cardiac Surgery,R654.2
  17. To Analysis the High Risky Factors of Our Hospital Coronary Artery by Pass Grafting,R654.2
  18. Effect of Limb Ischemic Conditioning on Lung Injury in Adults Undergoing Valve Replacement Surgery,R654.2
  19. Surgical Treatment of Pectus Excavatum,R726.5
  20. Dynamic Observation in Minimally Invasive Treatment of Cerebral Hemorrhage,R743.34
  21. Study the Dynamical Fluctuation of the Fibrinolytic Activity in Patients with Mini-invasive Hematoma Aspiration,R743.34

CLC: > Medicine, health > Surgery > Of surgery > Cardiovascular and lymphatic system surgery > Heart
© 2012 www.DissertationTopic.Net  Mobile