Dissertation > Excellent graduate degree dissertation topics show

Immunohistochemical Expression of APC/p63 in Tumorigenesis of Human Oral Squamous Cell Carcinoma: Correlation with Clinicopathological Features.

Author: NiuYing
Tutor: ZhuEnXin
School: Dalian Medical University
Course: Stomatology
Keywords: Oral squsmous cell carcinoma (OSCC) APC p63 Immunohistochemistry
CLC: R739.8
Type: Master's thesis
Year: 2006
Downloads: 52
Quote: 1
Read: Download Dissertation

Abstract


Background: The APC ( adenomatous polyposis coli ) tumor suppressor controls the stability of the wnt singaling pathway ,and is the key roles in the development of oral spuamous cell carcinoma. In the present study ,APC has been observed to act with important genes of colorectal carcinoma ,and regulate the wnt singaling pathway through bate-catenin degradation complex, which is essential for development and carcinogenesis in human oral squamous carcinoma. APC plays a central role in wnt singaling pathway which determines wnt stimulation and unormal-response. p63 also is a tumor suppressor which acts as important factor in the occurrence of oral squamous cell carcinoma. we have observed that there were some change in the level of the gene transcription product and the localization of APC and p63 in canceration of human tumor. Here , we analyzed each target tissue of normal squamous epithelium, epithelial dysplasia, and squamous cell carcinoma(SCC) of oral case, to make clear the machenism of APC in canceration of SCC.Objective: To investigate the prognostic value and clinicopathological significance of tumor suppressor APC and p63 , as well as their expression in oral squamous cell carcinoma (OSCC) .Methods: Immunohistochemical analysis of the expression of APC and p63, In which specimens including normal oral mucosa ,epithelial dysplasia and oral squamous cell carcinoma were performed in 46 OSCC cases of formalin fixed-paraffin embedded with elivision

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Study of Kisspeptin/GPR54 System on the Reproductive Regulation in the Hen’s Hypothalamus-Pituitary-Ovary Axis,S831
  3. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  4. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  5. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  6. Expression of MMP-9 and p63 in Oral Squamous Cell Carcinoma and Clinical Significance,R739.8
  7. Expressions of PRL-3 and p27 in Gastric Carcinoma and Their Clinical Significance,R735.2
  8. Expression of hnRNP A2/B1 and p21WAF1 Proteins in Lung Cancer and Their Clinical Significance,R734.2
  9. The Effects of RIP on the Immune Function of Renewal Rats Without Colostrums,S853.7
  10. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  11. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  12. Expression and Clinical Significance of Survivin and YAP in Cervical Carcinoma,R737.33
  13. Expression and Clinical Significance of PTEN and Caspase-7 in Gastric Cancer and Precancerous Lesion,R735.2
  14. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  15. Expression and Antibody Preparation of sglt1 from Cyprinus CarpioL.,S917.4
  16. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  17. Expression and Correlation of Caspase-3 and Cx43 in Myocardial Infarction with Different Narrow Degree Coronary Artery,R542.22
  18. The Expression and Relationships of Bmi-1 and c-myc in Diffuse Large B-cell Lymphoma Tissues,R733.1
  19. Expression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Pathological Changes of Sternocleidomastoid of Congenital Muscular Torticollis and Four Years Clinical Followed-up for Opereated Patients,R726.8
  20. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  21. Expression Characteristics and Clinical Significance of RECK in Cervical Cancer,R737.33

CLC: > Medicine, health > Oncology > Oral cavity, maxillofacial tumors
© 2012 www.DissertationTopic.Net  Mobile