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Expressions of HER2 and HER4 Isoforms and Their Significance in Pancreatic Ductal Adenocarcinoma

Author: YinYuFeng
Tutor: Zeng
School: Beijing Union Medical College
Course: Pathology and Pathophysiology
Keywords: Pancreatic Cancer Epidermal growth factor Immunohistochemistry Fluorescence in situ hybridization
CLC: R735.9
Type: Master's thesis
Year: 2010
Downloads: 28
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Abstract


Objective: To investigate HER2 and HER4 protein expression and gene status with the relationship between the development and the clinical and pathological features of pancreatic ductal adenocarcinoma ; explore pancreatic cancer between HER2 and HER4 protein and gene amplification on two levels and its clinical pathological significance. Method : using immunohistochemistry (IHC) and fluorescence in situ hybridization (FISH) detected 55 cases of pancreatic ductal adenocarcinoma HER2 and HER4 protein expression and gene status , including 21 cases of well-differentiated adenocarcinoma , 28 cases of moderately differentiated adenocarcinoma , six cases of poorly differentiated adenocarcinoma , and statistical analysis of the correlation between the correlation between the two protein expression of the corresponding gene status between its two clinicopathological features , as well as HER2 and HER4 respectively . Results : HER2 protein overexpression rate and the rate of gene amplification were 7.3% ( 4 / 55 ) and 9.1 % ( 5/ 55 ) ; HER4 protein expression rate and gene amplification rates were 3.6% ( 2 / 55 ) 3.6% ( 2 / 55 ) . Statistical analysis showed that : 1 ) the expression of HER2 protein or gene status and HER4 protein expression or gene status and the degree of differentiation of the tumor clinicopathological characteristics There was no significant correlation ( p gt ; 0.05) ; 2 ) HER2 protein expression and gene amplification no correlation ( p gt; 0.05 ) ; 3 ) HER4 protein expression and gene amplification was no correlation between sex ( p gt ; 0.05) : no correlation ( r ) between HER2 protein expression and HER4 protein expression = 0.05, p gt; 0.05) ; 5 ) of the HER2 gene status HER4 gene status , there was no significant correlation ( r = 0.06 , p gt ; 0.05) . Conclusion : 1) HER2 and HER4 has a relatively low rate of protein expression and gene amplification rate in pancreatic ductal adenocarcinoma ; 2 ) HER2 and HER4 with tumor differentiation degree clinicopathological features no correlation ; 3) HER2 and HER4 protein there is no correlation between the expression of gene amplification with breast cancer have been reported ; 4) HER2 and HER4 in pancreatic cancer did not show co-expression of the phenomenon also differ with breast cancer or head and neck cancer have been reported ; 5) HER2 or the HER4 whether potential as a pancreatic cancer drug therapeutic targets , pending further study .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Pancreatic tumors
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