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Objective: To investigate the relationship of cognitive dysfunction in patients with TCM syndromes and homocysteine ??(Hcy) hyperlipidemia and T2DM high Hcy hyperlipidemia and TCM Syndromes of type 2 diabetes mellitus (T2DM) and explore T2DM patients recognized knowledge dysfunction and high Hey hyperlipidemia-related risk factors, and provide reference for Chinese medicine, prevention and intervention of the T2DM cognitive dysfunction. Methods: 58 T2DM hospitalized T2DM group and 30 healthy volunteers as a control group, clinical Memory Scale (CMS) and the Mini Mental State Examination table (MMSE) evaluation of cognitive function, and complete serum Hcy concentration check Routine laboratory tests; development of TCM symptoms rating scale will T2DM component the three this card and three-card type, and the calculated syndrome type integral. Results: ① the T2DM group cognitive dysfunction incidence was significantly higher than that in the control group, the difference was statistically significant (χ 2 = 13.387, P lt; 0.001) the T2DM group memory quotient (MQ) and memory test various grades were significantly lower than the control group, between the two groups, a statistically significant difference (P lt; 0.05-0.001). ② T2DM group MQ TCM Syndrome Types. ③ T2DM serum Hey concentration is higher than that in the control group, the two groups have a significant difference (P lt; 0.01), and the concentration of serum Hey TCM Syndrome Types. (4) the control group, the T2DM cognitive function in normal group, T2DM cognitive dysfunction group concentration of serum Hey There were significant differences (P lt; 0.05 to 0.01) among the three groups. ⑤ MQ, TCM syndrome score and serum Hcy concentrations are closely related to the relationship between the three. ⑥ TCM symptom score between the the T2DM cognitive function obstacle group and T2DM cognitive function in the normal group, HbAlc, disease duration, TG, TC, HDL-C, ApoB, Hcy, systolic blood pressure compared to have statistically significant difference (P lt; 0.05 ); found no other factors significant difference. Linear relationship between the MQ with the course of the disease in patients with T2DM, TG, TC, HDL-C, HbAlc, systolic blood pressure, and no correlation with other factors. The ⑦ T2DM Hey group BUN, Cr higher than the T2DM normal Hcy group, two groups have a significant difference (P lt; 0.05). The T2DM group serum Hey concentration of BUN, Cr was positively correlated, with correlation coefficients (r = 0.259,0.343, P lt; 0.05), no correlation of other factors with serum Hcy concentration. ⑧ deficiency mixed syndrome group, TG, ApoB, Hcy, HDL-C, MQ, TCM syndrome scores alone deficiency syndrome group were statistically significant (P lt; 0.05 ~ 0.01), other indicators were compared between the two groups no statistical learning differences. Conclusion: ① T2DM patients with cognitive dysfunction with high Hcy hyperlipidemia, and both TCM. (2) the high Hcy hyperlipidemia may be risk factors for T2DM cognitive dysfunction, in addition to the duration of diabetes, HbA1c, TG, TC, HDL-C.ApoB, systolic blood pressure may affect T2DM cognitive dysfunction. ③ T2DM patients serum Hcy concentration of BUN, Cr, suggesting that high Hcy hyperlipidemia may be associated with T2DM renal dysfunction.
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