Dissertation > Excellent graduate degree dissertation topics show

Multiple -responsive supramolecular self-assembly behavior

Author: ZhangHuaCheng
Tutor: HaoAiYou;Prof.J.Fraser Stoddart
School: Shandong University
Course: Organic Chemistry
Keywords: Supramolecular self-assembly Host-guest inclusion Amphiphiles Cyclodextrin derivatives Self-assembled monolayer Inclusion ratio Arene Assembly behavior Self-assembly Amphiphilic Guest molecules Morphology Smart Materials One -dimensional Host-guest interactions arene Functional Host compound Methyl orange supramolecular
CLC: O641.3
Type: PhD thesis
Year: 2011
Downloads: 346
Quote: 0
Read: Download Dissertation

Abstract


This thesis is to study multi-responsive supramolecular self-assembly behavior as the theme, including two aspects: one, based on supramolecular cyclodextrin amphiphiles self-assembled multi-responsive behavior; Second, the functional column arene synthesis and self-assembly behavior. Among them, based on supramolecular cyclodextrin amphiphiles self-assembled multi-responsive behavior of the main direction of research consists of three parts: (a) novel supramolecular cyclodextrin amphiphiles design, synthesis and preparation. Conceptual theoretical level, based on supramolecular host-guest chemistry, in view of this thesis, summarize extensive literature has accumulated a large number of experimental data, and based on the supramolecular cyclodextrin amphiphiles the concept of a more comprehensive explanation and put a more complete \This ultra cyclodextrin molecule amphiphiles into three categories: (1) The first category supramolecular cyclodextrin amphiphiles refers covalent modification resulting amphiphilic cyclodextrin host compounds; (2) The second category is based on host-guest interactions, that is amphiphilic small molecules with cyclodextrins body build; (3) The third category is not amphiphilic hydrophobic guest molecules and cyclodextrins body build molecules through supramolecular interactions amphiphilic inclusion. As the field of supramolecular chemistry professor dean Reinhoudt, Ravoo Professor and Professor Darcy research group has already first class supramolecular cyclodextrin amphiphiles done a very comprehensive and detailed study, and proposed the formation of stable supramolecular self-assembly \Therefore, the main task of this thesis is the development of the second and third categories cyclodextrin supramolecular self-assembly of amphiphilic molecules and their behavior. The level of scientific thinking, research breakthroughs that part of the traditional mindset of the discovery of self-assembly of amphiphilic molecules system itself can be \Inclusion - The third category supramolecular cyclodextrin amphiphiles. Experimental methods and theoretical research, a series of new ferrocene derivatives and cyclodextrin derivatives have been synthesized for the preparation of the third class of supramolecular cyclodextrin amphiphiles. Meanwhile, the UV absorption spectra, cyclic voltammetry, hydrogen nuclear magnetic resonance spectroscopy (1D, 2D), fluorescence spectroscopy instruments such as test equipment, as well as based on the cyclic voltammetry, UV absorption, one-dimensional NMR spectroscopy of hydrogen continuous variation method (Job's plot), Benesi-Hildbrand formula, HAO Ai formula and other research methods have been used to study the third class of supramolecular cyclodextrin amphiphiles composition ratio, stability constants of nature and spatial conformation. (Two) based on novel supramolecular amphiphilic cyclodextrin molecules and supramolecular self-assembly behavior of multiple response nature. Through the second category supramolecular cyclodextrin amphiphiles - methyl orange, bromophenol blue and cyclodextrin derivative host-guest inclusion complexes, and obtained a series of vesicles with fluorescent activity system. Meanwhile, the paper by adjusting the pH of the system, the control system of self-assembled supramolecular macro color, microscopic morphology of aggregates to achieve a reversible supramolecular self-assembly system regulation. By the second class of supramolecular self-assembly of amphiphilic cyclodextrin aggregates system has been developed as supramolecular smart materials potential value. This article first developed by not having amphiphilic guest molecules - new ferrocene derivatives with the main cyclodextrin derivative-based supramolecular interactions formed the third category of supramolecular cyclodextrin amphiphiles now including the tadpole-and bola-type two systems. It should be noted that, through the use of a purpose of changing the molecular structure of the body and the solution system, can achieve a tadpole-and supramolecular bola type III cyclodextrins amphiphiles conversion between types, and by two-dimensional H NMR spectra, UV absorption spectroscopy, cyclic voltammetry, etc. been confirmed. The third category supramolecular amphiphilic cyclodextrin molecules can not \These supramolecular self-assembly morphology and size by transmission electron microscopy, scanning electron microscopy, atomic force microscopy, confocal microscopy, dynamic light scattering observation and research. Instrument testing methods based on these studies was based on preliminary supramolecular cyclodextrin amphiphiles supramolecular self-assembly mechanism. In addition, the third category supramolecular cyclodextrin amphiphiles form supramolecular aggregates with the characteristic response to external stimuli. As such supramolecular amphiphiles variety of solvents, electro-oxidation, chemical oxidation, pH and metal ions having a multiple response, making the aggregation behavior can be effectively regulated, the supramolecular aggregates with the development of intelligent materials, such as potential applications. (Three) multi-responsive supramolecular self-assembly behavior in controlled release drug delivery and multiple aspects of the application. The use of cyclodextrin-based supramolecular amphiphilic molecules in supramolecular self-assembly behavior specific response characteristics, developed the first based on supramolecular self-assembly of such a gradient-responsive drug delivery systems. Through hydrogen NMR spectrum, transmission electron microscopy, ultraviolet absorption spectrum, such as testing methods of research, found that by the third class of supramolecular cyclodextrin amphiphiles self-assembled drug-loaded vesicles system has a large amount of properties. In addition, hydrogen NMR spectrum, UV absorption spectroscopy, transmission electron microscopy and dynamic light scattering study also found that the third type of supramolecular cyclodextrin amphiphiles supramolecular self-assembly system can also turn on the pH and chemical oxidants response in nature and release the entrapped gradient of the drug molecules. Second, the function of the column aromatic derivatives and their self-assembly behavior. (A) This paper first proposed the concept of Dynamic Smart Click on the surface, and using azobenzene-modified column arene successfully constructed Dynamic Intelligent Click surfaces. New azobenzene-modified column arene was designed, synthesized and characterized. In the mixed solution of critical self-assembly concentration indicates the possible existence of self-assembly behavior. By negative staining electron microscopy, cryogenic transmission electron microscopy, scanning electron microscopy, environmental scanning electron microscopy, atomic force microscopy and dynamic light scattering method based on azobenzene-modified column arene supramolecular self-assembly forms. In addition, through a one-dimensional, two-dimensional NMR spectra of hydrogen supramolecular self-assembly behavior of its mechanism. Click with different surface traditional static, dynamic intelligence click against the outside surface of the stimuli can change its shape has a self-assembly. (Two) the use of azobenzene-modified column arene build the first column based arene derivatives, with reversible supramolecular self-assembly system. Changing the visible and ultraviolet radiation, so that this surface has a variable dynamic intelligence morphology can be converted vesicles and solid particles. By UV spectroscopy, transmission electron microscopy, dynamic light scattering, UV and visible light on the response of these behaviors are studied. With the previous structure containing azobenzene compound different from the assembled gathering system, the system is exposed to UV light will not disappear, but after the change in the external environment, reversible aggregation restored to its original form. Therefore, the system is both sensitive to ultraviolet radiation, but also a \This light-sensitive column arene self-assembly because the surface has a lot of body recognition sites and has broad prospects for development, such as can be applied as a \

Related Dissertations

  1. Research on Design of Teaching Buildings for Arts Departments of Higher Learning Institutions,TU244.3
  2. Tongue Feature Extraction and Research of Fusion Classification,TP391.41
  3. The Properties of Laser Speckle Based on the Mathematical Morphology,O29
  4. Research and Development of Wear Resistance for Physically Disabled Men Jackets,TS941.2
  5. Reaserch on the Effect of Fabric Structure on the Performance of Seamless Sports Underwear,TS941.15
  6. The Research on the Comprehensive Modification Technology of Rice Protein Enzymatichydrolysis and Graft Copolymerization,TS201.2
  7. Road extraction algorithm based on region segmentation of remote sensing image,TP751
  8. Research of Anomaly Detection Algorithms of Hyperspectral Imagery Based on Kernel Method,TP751
  9. Effects of Nitrogen Fertilizer on Morphological Development of Alfalfa Root,S541.9
  10. Functional Realization of the Competitive Selection System,D262.3
  11. Funcational Verification of Multifunction Vehicle Bus Controllor,TP273
  12. Studies on Leaf Epidermal and Pollen Micro-morphology and Geographical Distribution of the Genus Euonymus of Henan,Q944
  13. Sagitta Morephology, Distribution, Biology and Stock Assessment of Four Prlagic Species in the Mouth of Beibu Gulf,S932.4
  14. Technology of Blood Vessel Diameter Measurement Automatic Based on Digital Image Processing,R310
  15. Macrobenthic Secodary Production at Tianhe Inertial, Wenzhou,Q958.8
  16. Cloning and Functional Analysis of Lytic Enzyme Production Related Gene Ctp in Lysobacter Enzymogenes Strain OH11,TQ925
  17. The Research on the Modification and Functional Properties of Rice Glutelin,TS201.21
  18. The Evolvement of Quartzs and Phytoliths in Basalt-Derived Chronosequence Soils in Tropics Area of China,S153
  19. Study on Host Selection of Encarsia Sophia between Bemisia Tabaci B-Biotype and Q-Biotype Nymph,S476.3
  20. Study on the Morphology, Physiology and QTLS Mapping of a Dwarf Mutant Ari1327 from Cotton (Gossypium Hirsutum L.),S562
  21. Proteomic Research of Rice Plasma Membrane Protein under Blast Stress,S511

CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Structural Chemistry > Molecular interactions,supramolecular chemistry
© 2012 www.DissertationTopic.Net  Mobile