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Magnetic nano liposome doxorubicin targeted therapy experimental study of colorectal cancer in nude mice

Author: ZhouPingHong
Tutor: QinXinYu
School: Fudan University
Course: Surgery
Keywords: Tumor Targeted therapy Drug Carriers Liposomes Magnetic drug Doxorubicin Nano
CLC: R735.3
Type: PhD thesis
Year: 2003
Downloads: 719
Quote: 5
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Abstract


Conventional routes of administration , low therapeutic index of chemotherapy drugs , poor patient compliance . Targeted cancer therapy is the use of a particular carrier of chemotherapy drugs at specific action oriented mechanism selectively positioned in the tumor tissue , increase the concentration of the drug within the tumor tissue , to improve efficacy, reduce toxic side effects and increase patient compliance purposes . In this series of experiments, we used reverse phase evaporation method developed nanoscale magnetic liposomal doxorubicin , doxorubicin investigated magnetic nano liposome stability in vitro , in vivo and in response to an external magnetic field of colorectal cancer in nude mice biodistribution , observed the magnetic nano liposome doxorubicin colorectal cancer growth in nude mice . The results showed that: ( 1) Magnetic nano liposome doxorubicin average particle diameter 230nm, 25% encapsulation of doxorubicin , the magnetic particles are uniformly distributed in the liposomes . Different lipid ratio of drug to lipid ratio, type of organic solvent and water phase volume ratio affects the magnetic liposomal doxorubicin nano particle size and encapsulation efficiency of doxorubicin . After preparation 40C preservation, low leakage rate within 8 hours . The results suggest that magnetic nano liposome doxorubicin may be used as a new carrier should be targeted in the treatment of malignant tumors . ( 2 ) magnetic nano liposome doxorubicin in vitro , in vivo magnetic field has a good response . Application of magnetic nano liposomes administered in a magnetic field , can effectively gather doxorubicin to the target site, the target site significantly increased the concentration of doxorubicin , reducing the heart , kidney tissue drug concentrations . As an effective carrier of doxorubicin , magnetic nano liposome delivery methods applied magnetic field is expected to become a new way to targeted cancer therapy . ( 3 ) in nude mice implanted colorectal tumor tissue after intravenous injection of the permanent magnet magnetic nano liposome doxorubicin , can significantly inhibit the growth of tumor tissue . This study suggests that the new carrier as a chemotherapeutic agent , magnetic nano- liposomes at the tumor site under the effect of a magnetic field can effectively improve the chemotherapy drug concentrations in tumor tissue , reducing toxicity of chemotherapy drugs , significantly inhibited tumor growth. This study is a magnetic nano- liposomes as carriers of chemotherapy drugs used in clinical cancer therapy further foundation . Targeted therapy may become a new method of cancer therapy .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms
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