Dissertation > Excellent graduate degree dissertation topics show

Levamlodipine Besylate Tablets treatment of mild and moderate primary hypertension clinical research

Author: JiaTan
Tutor: YuJinMing
School: Fudan University
Course: Public Health
Keywords: Essential hypertension L-amlodipine besylate Amlodipine maleate Randomised active-control clinical trial
CLC: R544.1
Type: Master's thesis
Year: 2011
Downloads: 64
Quote: 0
Read: Download Dissertation


Objective:To evaluate the effectiveness and safety of L-amlodipine besylate in patients with mild to moderate essential hypertension.Method:A total of 1051 mild to moderate essential hypertensives was selected from 22 centres and randomized into three groups and were given low-dose L-amlodipine besylate (2.5mg/d, group A), amlodipine maleate (5mg/d, group B), and high-dose L-amlodipine besylate (5mg/d, group C) on the principle of double-blind and parellel control. The study drugs were administered 8 weeks and evaluated.Results:After 8 weeks treatment, the response rate of the three groups were 68.1%,69.1%, and 79.4%, respectively. The rate difference between group A and B was-1.1%, with-7.9% and 5.8%as 95%confidence interval. It met the bound of non-inferiority test, which was 10%. The rate diference between group C and B was statistically significant (P=0.0014). The event rates of the three groups were 4.3%,5.1%, and 4.6%, respectively, with no statistically difference.Conclusion:Low-dose L-amlodipine besylate showed non-inferiority with amlodipine maleate on the effectivel effectiveness in patients with mild to moderate essential hypertension, while high-dose L-amlodipine besylate was superior than amlodipine maleate. There was no significant difference between the safety profiles of the three groups.

Related Dissertations

  1. Clinical Study on Relationship Among Syndrome Differentiation Clssified in Tcm,ambulatory Blood Pressure Monitoring and Transcranial Doppler in Essential Hypertension,R259
  2. Heterogeneity and Meta Analysis of the Essential Hypertension Risk Assessments,R544.1
  3. Effects of Telmisartan on hs-CRP and HMW-adiponectinin Patients with Essential Hypertension,R544.1
  4. Preliminary Study of Left Atrial Volume and Left Ventricular Volume Changes in Essential Hypertensive Elderly Patients,R544.1
  5. Effect of Telmisartan and Benazepril on the Activity of Endothelial Lipase and Levels of Adiponectin in Patients with Mild Essential Hypertension,R544.1
  6. Association of Genetic Polymorphism in Brain Natriuretic Peptide with Essential Hypertension in Hunan Han,R544.1
  7. Analysis of Relationship between the A-6G Polymorphism of the Promoter Region of Angiotensinogen Gene and Essential Hypertension in Bai Nation,R544.1
  8. Analysis of Etiology of In-patients with Hypertension from Grade AAA Hospital in Xinjiang,R544.1
  9. The Relationship between the Level of Homocysteine and Important Target Organs Damage in Essential Hypertension.,R544.1
  10. Research of Blood Pressure Variability’s Influence on Arery Stifiness and Left Ventricular Hypertophy in Hypertnesiv Patients,R544.1
  11. Clinical Evidences Evaluation about Liver Excess and Kidney Deficiency in Essential Hypertension Based on Systematic Review,R259
  12. Clinical Application Study in Self-made ShengjiSan Treat Chronic Ulcer of Skin,R275.9
  13. The Interventional Effects of Xuezhikang and Pravastatin on Serum NO, ET, HS-CRP, IL-1 and TNF-α in Simple Essential Hypertensive Patients,R544.1
  14. Correlation between Angiotensinogen Gene M235T Polymorphism and Essential Hypertension in the Bai Nationality,R544.1
  15. Plasma Retinol Binding Protein 4 Level and Its Correlation in Patients with Essential Hypertension of Kazakans,R544.1
  16. Clinical Study on Treation Primary Hypertension with Gastrodia and Uncaria Decoction,R259
  17. The Large Arterial elasticity influencing factors,R544.1
  18. Clinical Research on Chinese and Western Medicine Combined Program of Intervention in Elderly Hypertensive Patients with Early Renal Damage,R544.1
  19. The Relation between Plasma Kallikrein B1 and Bradykinin B2 Receptor Gene SNP, BMI and Essential Hypertension,R544.1
  20. Study on Plasma NO, H2S Levels and Their Correlations in Pations with Essential Hypertension of Kazakhs,R544.1
  21. The Effect of Anxiety Depression on Blood Pressure and Heart Rate Variability in Patients with Hypertension,R544.1

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
© 2012 www.DissertationTopic.Net  Mobile