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Medical dressings trauma to the surface of the wound from bacterial infections and other external factors affect medical materials play a protective effect on the wound, the wound. The bacterial cellulose (BC) is a natural biopolymer, has unique physical, chemical and mechanical properties, such as: the high degree of crystallization, high water content (98-99%), high tensile strength and chemical purity, etc. . BC absorb the heat of the burned area to reduce pain, and to protect the wound from secondary infection and mechanical damage, and will not stick to the new tissue can make the wound heal faster, good permeability, with ordinary medical dressings This material is conducive to the rapid growth of the skin. Very much in line with the requirements of the standards of modern wound dressings, is known as a natural wound dressing. This paper Plackett-Burman (PB), a non-fully balanced block principle-based test design method, filter out the four main influencing factors, and then using the Box-Behnten central composite experimental design and response surface methods (RSM) defined medium. good concentration of glucose 2.210%, 1.000% of yeast extract peptone, 0.20% of citric acid, 0.30% of disodium hydrogen phosphate, potassium dihydrogen phosphate 0.30%, magnesium sulfate 0.30%. Access to 12% of the fermentation medium of the seed culture was thoroughly shaken after inoculation, and a constant temperature of 30 ° C was allowed to stand for six days of culture. Under these conditions, the production of bacterial cellulose film 6.737g/0.1L. Secondly, as medical dressings, based on static culture, this paper respectively reference GB/T1014.1-2006, GB/T1038-2000, GB/T1037-88 of the bacterial cellulose membrane elastic modulus, permeability, water vapor permeability study, study reference the medical dressings standards YY0471-2006 performance surface of bacterial cellulose membrane antibacterial (Staphylococcus aureus and Escherichia coli), while the analysis of the structure and properties of the bacterial cellulose film. Including: scanning electron microscopy, X-ray diffraction patterns, water holding capacity and its applications in medicine and laid the foundation. Production of bacterial cellulose film, this material can be sterilized, but also biocompatible, porous, flexible, easy-to-storage processing, easy to absorb exudate, is conducive to the growth of skin tissue and restrictions infection, so to explore the possibility of bacterial cellulose as a medical dressing. The bacterial cellulose rabbit skin wound healing of experiments: bacterial cellulose film is applied to the wound, can inhibit the early inflammatory response. Bacterial cellulose film experimental group compared with the control group, wound wound healing rate in the first eight days of the experimental group improved significantly; 13 days after the wound site in the experimental group hurt scab completely falling fresh granulation tissue formation, while the control group still little knot scab healing after 20 days. Bacterial cellulose film on the skin traumatic injury have a therapeutic effect.
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