Dissertation > Excellent graduate degree dissertation topics show

The Expression of RGS2Protein in Non-small Cell Lung Cancer

Author: HuangQingYun
Tutor: HuangQi
School: Huazhong University of Science and Technology
Course: Surgery
Keywords: Non-small cell lung cancer(NSCLC) RGS2 immunohistochemistry
CLC: R734.2
Type: Master's thesis
Year: 2013
Downloads: 1
Quote: 0
Read: Download Dissertation

Abstract


Objective The G protein regulating factors2(RGS2) has related to thedevelopment of a variety of malignant tumors. We investigated the expressive levelof RGS2protein in cancer tissues, corresponding adjacent lung tissues and normaltissues of non-small cell lung cancer (NSCLC) patients and the relationship of RGS2protein with clinical pathological features. Then, we explore it‘s role incarcinogenesis and progression of NSCLC and evaluate their clinicopathologicsignificances.Methods Immunohistochemical technique was used to detect theexpressive leves of RGS2protein in83cancer tissues,83corresponding adjacent lungtissues and56normal lung tissues of83non-small cell lung cancer patients. ThenSPSS13.0software was applied for statistical treatment. We analysed the date resultsby Chi-square test and Fisher’s exact probability method to detect the expressiondifferences of RGS2proteins in the lung cancer tissues, the corresponding adjacentlung tissues and normal tissues and its relationship with clinical pathological featuresof NSCLC. Results (1)The positive rate of RGS2protein in non-small cell lung cancertissues (74.7%) was higher than in corresponding adjacent lung tissues (20.5%)and normal tissues (8.9%)(χ~2=78.474, P<0.01).(2) The positive rate of RGS2protein in stage I, stage II and stage (III+IV) was52.9%,67.9%and89.5%respectively, the difference was significant (χ~2=9.341,P<0.01).(3) The positive rate(89.5%) of RGS2protein in the lymph node-positive grope was higher than the rate(62.2%) in the lymph node-negative grope, their difference was significant(χ~2=8.095, P<0.01).Conclusion RGS2protein is higher expressed in NSCLC and associated withmalignant degree of tumor；It play an important role in the carcinogenesis andprogression of NSCLC. RGS2protein might be an important biomarker in theevaluation of the biological behavior of NSCLC.

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Study of Kisspeptin/GPR54 System on the Reproductive Regulation in the Hen’s Hypothalamus-Pituitary-Ovary Axis,S831
  3. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  4. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  5. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  6. Expressions of PRL-3 and p27 in Gastric Carcinoma and Their Clinical Significance,R735.2
  7. Expression of hnRNP A2/B1 and p21WAF1 Proteins in Lung Cancer and Their Clinical Significance,R734.2
  8. The Effects of RIP on the Immune Function of Renewal Rats Without Colostrums,S853.7
  9. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  10. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  11. Expression and Clinical Significance of Survivin and YAP in Cervical Carcinoma,R737.33
  12. Expression and Clinical Significance of PTEN and Caspase-7 in Gastric Cancer and Precancerous Lesion,R735.2
  13. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  14. Expression and Antibody Preparation of sglt1 from Cyprinus CarpioL.,S917.4
  15. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  16. Expression and Correlation of Caspase-3 and Cx43 in Myocardial Infarction with Different Narrow Degree Coronary Artery,R542.22
  17. The Expression and Relationships of Bmi-1 and c-myc in Diffuse Large B-cell Lymphoma Tissues,R733.1
  18. Expression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Pathological Changes of Sternocleidomastoid of Congenital Muscular Torticollis and Four Years Clinical Followed-up for Opereated Patients,R726.8
  19. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  20. Expression Characteristics and Clinical Significance of RECK in Cervical Cancer,R737.33
  21. Study on Expression of Minichromosome Maintenance Proteins2、7 in Primary Squamous Cell Carcinoma and Cervical Intraepithelial Neoplasia and Its Significance,R737.33

CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
© 2012 www.DissertationTopic.Net  Mobile