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Objective: To evaluate the parecoxib sodium and fentanyl for of gynecological postoperative patient controlled intravenous analgesia effect; observed combination of parecoxib sodium can reduce the dose of fentanyl and adverse reactions; explore parecoxib sodium Postoperative analgesia combined with fentanyl of gynecological patients immune function. Methods: 100 cases of uterine fibroids period abdominal hysterectomy were randomly divided into two groups (n = 50), under the Optional lumbar epidural anesthesia at the end of surgery, group A patients intravenous Parry celecoxib sodium 40 mg and connect PCIA pump (fentanyl 1.0mg, and Tropisetron 4mg join saline to 100 ml, set the background dose of 1ml / h, automatic control 2m1 / dose, lockout time 15min). PCIA pump is connected to the end of the Group B patients surgery (fentanyl 1.0mg and tropisetron 4mg, adding saline to 100 ml set the background dose 1ml / h Controls 2ml / dose, lockout time 15min). Were observed after 4 h, 8 h, 12 h, 24-h the 48h visual analogue scale (VAS score), respectively, before surgery (T0), surgery completed (T1), postoperative 12h (T2), surgery after 24h (T3), postoperative 48h (T4) at five time points extracted peripheral venous blood plasma IL-6 level of content of IL-10 and T-lymphocyte subsets (CD, CD4, CD8) and CD4 / CD8 the ratio of the actual number of pressing, recorded after 48h fentanyl dosage, PCIA pump, effectively pressing the number of D / D ratio and analgesia during adverse reactions occurred a number of cases. Results: 1. General information, patients were age, weight, height, operation time compared the difference was not statistically significance (P gt; 0.05). 2 patients VAS score difference was not statistically significant (P gt; 0.05). The difference was statistically significant (P lt; 0.05) 3. Postoperative incidence of adverse reactions. . 48h after PCIA pump pressing times, effectively PCIA pump pressing times and the amount of fentanyl in group A are less than the B group, the difference was statistically significant (P lt; 0.05). The two sets of D / D ratio difference was not statistically significant (P gt; 0.05). Patients at T0 IL-6, IL-10 content and the level of T lymphocyte subsets (CD3, CD4, CD8) and CD4 / CD8 ratio was no significant difference (P gt; 0.05). Groups IL-6, IL-10 in T1, T2, T3, T4 time points compared with T0 were significantly elevated (P lt; 0.05), but the group B of the IL-6 levels were in T2, T3, T4 point in time higher than the A group, the difference was statistically significant (P lt; 0.05). IL-10 levels in group B at T2, T3, T4 time points were lower than the A group, the difference was statistically significant (P lt; 0.05). Two groups of patients with T1, T2, T3, T4 time points CD3, CD4 molecule CD4 / CD8 ratio level compared To have a decline in group B at T2, T3, T4 time point decline were higher than group A The differences were statistically significant (P lt; 0.05). The two groups of patients with T1, T2, T3, T4 time points CD8 levels did not change significantly compared to T0, the difference was not statistically significance (P gt; 0.05). Conclusion: parecoxib sodium and fentanyl used in gynecological patients, postoperative analgesia; reduced dosage of fentanyl; patients with postoperative nausea, vomiting, pruritus, and other adverse reactions; alleviate post-operative trauma inflammatory a slight reaction, immune suppression, immune function after quick recovery.
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