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Research on Expressions and Significance of CtBP2 in Non-small Cell Lung Cancer and Its Relationship with p53

Author: ZhangChenCe
Tutor: ShenYi
School: Qingdao University
Course: Surgery
Keywords: Non-small cell lung cancer Immunohistochemistry RT-PCR CtBP2 p53
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 10
Quote: 0
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Abstract


Objective:To explore the expressions of CtBP2 in non-small cell lung cancer (NSCLC) and their significance, to analyse its relationship with p53.Method:PV immunohistochemical method was used to examine the expressions of CtBP2 and p53 in 60 NSLC patients, the relationship between the expressions and pathologic staging, differentiation, lymph node metastasis, and relationship with p53 were analyzed. The normal tissue away from the cancer was taken from 20 cases served as comparisons. Reverse Transcription Polymerase Chain Reaction (RT-PCR) method was used to examine the expressions of CtBP2 in 40 NSLC patients, the relationship between the expressions and pathologic staging, differentiation, and lymph node metastasis were analyzed. The normal tissue away from the cancer was taken from 20 cases served as comparisons.Results:Results of immunohistochemical:The differences of expressions of CtBP2 between cancer tissue and paraneoplastic were significant (P<0.05), the expressions of CtBP2 were correlated with lymphatic metastasis (P<0.01). The expression of CtBP2 was positively correlated with p53 in NSCLC tissues (P<0.01). Results of RT-PCR:The differences of expressions of CtBP2 between cancer tissue and paraneoplastic were significant (P<0.01), the expressions of CtBP2 were correlated with lymphatic metastasis (P<0.01).Conclusion:Imbalance of the expressions of CtBP2 is associated with the occurrence and development of non-small cell lung cancer, its mechanism maybe associated with p53 gene.

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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