Dissertation > Excellent graduate degree dissertation topics show

The lecithin liposomes Quantitative structure function relationship studies

Author: YuanSong
Tutor: DingLiXia；SunHuiMin
School: Chinese Pharmaceutical and Biological Products
Course: Drug analysis
Keywords: Liposomes Phosphatidyl choline Stability Fatty acid chains Saturation
CLC: R943
Type: Master's thesis
Year: 2011
Downloads: 102
Quote: 0
Read: Download Dissertation

Abstract

Liposomes are phospholipid is dispersed in water to form a spherical, the encapsulating part of the aqueous phase of the closed vesicle, similar biofilm due to its structure, it is also known as artificial membrane. The liposomes have is encapsulated drug stability, targeting, long-term, to reduce the use of dose characteristics are widely used in drug carrier, the liposome of the liquid is a suspension during storage easily aggregation, integration, and led to the inclusion of drug leakage. Therefore, it is necessary to carry out a systematic study of factors affecting the stability of the liposomes. Phospholipids are the main membrane of the liposome, especially phosphatidyl choline is the most commonly used, the phosphatidylcholine can be divided into different categories depending on the fatty acid chain, the preparation of liposomes of different fatty acid chains of phosphatidyl choline determine the selection of the following studies: (1) Preparation process tartrate indenyl quinolone morpholine as a water-soluble model drug, prepared tartaric indene quinolizin Novo morpholine liposomes. Using reverse evaporation Preparation of tartaric acid indene quinolone morpholine liposomes. The using the glucan gel column chromatography to separate the free drug and liposome calculated liposomes rate. Box-Behnken response surface curves to determine the best preparation of tartaric indene quinolone-liposome encapsulation efficiency and particle size of the indicators, the results showed that the prepared liposome encapsulation efficiency was 44.34%, with Box-Behnken response surface curve software calculated the highest encapsulation efficiency close to 44.68%. (2) to study the differences in the physical stability of the preparation of different structures phospholipid indenyl quinolone morpholine tartrate liposomes. To determine the optimal preparation of dimyristoyl phosphatidyl choline, dipalmitoyl phosphatidyl choline, distearoyl phosphatidyl choline, dioleoyl phosphatidyl choline prepared tartaric inden-quinolone-lipid body, compare the preparation of liposomes stability parameters. The findings prepared as the chain length of the fatty acid chains in the liposome particle size and phosphatidylcholine positively correlated, negatively correlated with the degree of unsaturation of the fatty acid chain; the rate of hydrolysis of the liposomes with a fatty acid chain length was negatively related with the unsaturated degrees into positive correlation. (3) prepared the activation energy of the aggregation of the liposomes by condensation activation energy determines the stability of the liposomes. According to the data presented the relationship between the fatty acid chains in the liposome stability of the water-soluble drug Composite Index and phosphatidyl choline, calculated stability of the liposomes according to the cohesion stability of the activation energy judgment liposomes consistent. That the relationship can be used to determine the stability of the preparation of liposomes of different phosphatidylcholine.

The lecithin liposomes Quantitative structure function relationship studies

Abstract

Related Dissertations