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Expression of DICER Protein in Non-small Cell Lung Cancer and Its Correlation with Cancerous Cell Proliferation

Author: ZhangShaoZhong
Tutor: XiangXiaoYong；ChenLi
School: Chongqing Medical University
Course: Surgery
Keywords: Dicer Cancer cell proliferation Non - small cell lung cancer Immunohistochemistry PCNA protein
CLC: R734.2
Type: Master's thesis
Year: 2011
Downloads: 16
Quote: 0
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Abstract


Objective: To detect non-small cell lung cancer (NSCLC) organization endonuclease Dicer, proliferating cell nuclear antigen (Proliferating cell nuclear antigen, PCNA) protein expression , analysis of the relationship of the significance of clinical and pathological features of Dicer protein expression in NSCLC explore Dicer protein and cancer cell proliferation in the mutual relations . Methods: Using immunohistochemistry SP method detected Dicer protein , PCNA protein in 57 cases of lung cancer and 16 patients with paraneoplastic normal lung tissue expression analysis , combined with the clinical and pathological features of lung cancer . Results: 57 patients with non-small cell lung cancer Dicer protein loss expression rate of 50.9% , and 37.5 % in 16 cases of cancer and adjacent normal lung tissue , the difference was not statistically significant ( P gt ; 0.05) ; expression of Dicer protein in lung adenocarcinoma lost rate 66.7% of squamous cell carcinoma was 37.0 % , both significantly different ( P lt; 0.05 ) ; of Dicer loss of expression of the protein in well-differentiated carcinoma group (33.3%) was lower than poorly differentiated carcinoma group (76.5 %) , both significant differences the average PCNA index (P lt; 0.05); while pTNM stage , lymph node metastasis , and age, gender unrelated ( P gt ; 0.05) ; Dicer expression and low expression of NSCLC cancer tissues (37.61 ± 20.31)%, respectively. (48.32 ± 25.34)%, P gt; 0.05. Conclusions : (1) of Dicer protein loss of expression may be involved in the occurrence of lung adenocarcinoma development process , it is possible to become a reliable indicator for early diagnosis of lung adenocarcinoma . (2) Dicer gene mutation may affect the direction of differentiation of the tumor cells , as the protein loss higher expression rate , the worse the degree of differentiation of the lung cancer cells . (3) Dicer protein does not directly affect the expression of PCNA protein , no direct relationship with the lung cancer cell proliferation .

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CLC: > Medicine, health > Oncology > Respiratory system tumors > Lung tumors
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