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1965 Lauren organizational structure and biological behavior of gastric, gastric cancer is divided into intestinal-type and diffuse-type, later known as Lauren type. The parting is not only reflect the biological behavior of the tumor, but also reflect the etiology, pathogenesis and epidemiological characteristics. Intestinal type gastric cancer generally have significant ductal structures, the tumor cells were columnar or cuboidal visible intestinal metaplasia. Intestinal type gastric longer course, have a higher prevalence, more common in older men, a better prognosis, is often considered secondary to chronic atrophic gastritis. Diffuse gastric cancer cells showed diffuse growth, lack of cell junctions, and generally do not form glandular differentiation poor. Compared with intestinal type gastric cancer and diffuse gastric cancer is less affected by the environment, and is more common in young women, prone to lymph node metastasis and distant metastasis, and poor prognosis. Recent studies have shown that part of the diffuse-type gastric cancer familial aggregation and heredity. We collected Huashan Hospital, Fudan University, November 2008 to February 2009, 100 patients with gastric cancer biopsy (gastroscopy specimens biopsy, part of the biopsy specimens), intestinal-type and diffuse-type distinction and compare two types of clinical and pathological features. Objective: 1. Comparison intestinal-type and diffuse-type gastric distinction of clinical features and biological behavior; 2. Comparison for gastric Immunohistochemical detection of ELISA positive percentage intestinal-type and diffuse-type gastric cancer whether statistics learning differences. Method: 1. Collect Fudan University Huashan Hospital from November 2008 to February 2009, 100 patients with gastric cancer biopsy (17 cases in which the gastroscope biopsy, surgical specimens sliced ??83 cases, according to WHO Lauren classification standards genotyping of intestinal-type and diffuse-type; compared patients with intestinal-type and diffuse-type in the pathogenesis of age, sex, tumor location, depth of invasion, lymph node metastasis number distinction; statistics currently used in gastric pathology immunohistochemistry of various ELISA positive percentage intestinal-type and diffuse-type. Results: In this study were collected pathologically confirmed 100 cases of gastric cancer patients biopsy, diffuse which intestinal type of 46 people (36 men, 10 women); 42 people (28 males, 14 females); the hybrid 9 (7 men, 2 women); undifferentiated carcinoma 2 people (1 male, 1 female); carcinoid 1 person (male). gastric cancer patients in intestinal type gastric cancer accounted for 46% of diffuse-type gastric cancer accounted for 42%, and mixed type gastric cancer (9%); 49.3% of male patients with gastric intestinal-type, diffuse type accounted for 38.4%, mixed 9.6% in female patients with gastric intestinal-type 37.0%, 51.9% diffuse mixed accounted for 7.4%; gender distribution of the three types that there was no statistical difference (0.25 16, diffuse-type gastric cancer lymph node metastasis number ,1-6 8 0 17 7 - 15, 8, 4 16 hybrid lymph node transfer number 0, 6, 1 - 6 0 7 - 15, 1, 16, 0, 3 types of difference in the number of lymph node metastasis was statistically significant (0.025 0.05, not think statistically different between the two. intestinal type of P53 average positive rate = 1.638, S = 1.222; diffuse P53 average positive rate = 1.314, S = 0.9632; t = 0.2674, P> 0.05, can not be considered statistically different between the two. Conclusions: Based on the information obtained in this article statistical results, intestinal type gastric cancer, diffuse gastric cancer and mixed-type gastric cancer in the gender distribution, the distribution of the location of the tumor in the stomach, the depth of tumor invasion was no statistical difference, there is a statistically significant difference in the average age, the average age of the diffuse statistically different intestinal type (P <0.01) less than in a number of aspects of the metastatic lymph nodes, metastasis of lymph node number 0 of intestinal type gastric cancer than diffuse-type gastric cancer (0.025 |