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Objective: To observe the benazepril protective effect in diabetic rat heart function . Methods: male Sprague-Dawley (SD) rats by intraperitoneal injection of streptozotocin (STZ) - induced diabetes model . The successful modeling of the rats were randomly divided into diabetic group and benazepril group , and not STZ injection in rats as the control group . The control group and the diabetic group to tap water orally , benazepril group to the benazepril powder tap water for dissolved after gavage . After 8 weeks I The cardiac ultrasound measurement of left ventricular end-diastolic diameter (LVIDD), left ventricular systolic diameter ( LVIDS ) , ejection fraction ( EF ) , fractional shortening rate ( FS ) , hemodynamics measured left chamber peak pressure (LVSP), left ventricular end-diastolic pressure (LVEDP), left ventricular pressure rise (dp / dt) the and dropped the rate ( -dp/dt ) , and measured heart weight index . : Echocardiographic results : Compared with the control group the the diabetic group LVIDD [ ( 6.79 ± 0.58 ) vs ( 7.73 ± 1.19 ) mm , p lt ; 0.05 ] , heart rate [ ( 350 ± 54 ) vs ( 432 ± 44) bpm p- lt ; 0.01 FS [ ( 37.15 ± 8.81 ) vs (52.04 ± 9.68 ) % , p- lt ; 0.01 ] , EF [ ( 0.72 ± 0.11 ) vs ( 0.86 ± 0.09 ) , p- lt ; 0.01 ] significantly significantly reduced ; with compared to the diabetic group , benazepril group LVIDS [ ( 3.74 ± 0.64) vs ( 4.25 ± 0.53 ) mm , p lt; 0.05 ] significantly reduced heart rate [ ( 382 ± 23 ) vs ( 350 ± 54 ) bpm , p lt Hemodynamics : Compared with the control group , diabetic group dp / dt [ ( 4044.66 ± 1318.27 ) vs ( 6015.63 ± 905.70 ) mmHg / s , p lt ; 0.05] significantly decreased LVSP, LVEDP , -dp/dt significant difference ; compared with the diabetic group , benazepril group dp / dt [ ( 5424.27 ± 923.68 ) vs ( 4044.66 ± 1318.27 ) mmHg / s, p lt; 0.05 ] a significant increase in LVSP , LVEDP , -dp/dt There was no significant difference . Compared with the control group , diabetic group weight ( 221 ± 46 ) vs ( 421 ± 62 ) g , p lt ; 0.01] significantly decreased heart weight index ( 4.07 ± 0.67 ) vs ( 3.23 ± 0.14 ) mg / g , p <0.01] increased significantly ; compared with the diabetes group , benazepril the Plymouth group body weight and heart weight index no statistically significant difference . Conclusion : of STZ -induced diabetic rats at 8 weeks , cardiac insufficiency, benazepril diabetic rat heart function has a protective effect .
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