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Expression and Significance of HSP27 and TFF2 in Human Gastric Cancer and Precancerous Disease

Author: RongFang
Tutor: HouHeng;LiLiFen
School: Shanxi Medical
Course: Department of Gastroenterology,
Keywords: Heat shock protein 27 Trefoil Factor II Immunohistochemistry
CLC: R735.2
Type: Master's thesis
Year: 2008
Downloads: 64
Quote: 0
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Abstract


Objective: To investigate the heat shock protein 27 ( Heat shock protein27 , HSP27 ) , trefoil factor Ⅱ (Trefoilfactors2, TFF2) expression in gastric cancer and precancerous diseases and clinical significance . Methods: Immunohistochemistry (SABC) of 120 patients with pathologically confirmed 20 cases of normal gastric mucosa , gastric ulcer in 22 cases, 24 cases of chronic atrophic gastritis and gastric cancer 54 cases of HSP27 and TFF2 expression by image analysis software on HSP27 and TFF2 the average optical density were measured, and clinically relevant information for statistical analysis . Results : 1.HSP27 slower atrophic gastritis ( 0.305 ± 0.010 ) expression in normal gastric mucosa ( 0.291 ± 0.012 ) and gastric ulcer ( 0.302 ± 0.011 ) , chronic atrophic gastritis and normal gastric mucosa difference was statistically significance ( P < 0.05 ) . Expression of gastric cancer ( 0.314 ± 0.018 ) compared with the first three , the difference was statistically significant ( P < 0.05 ) . HSP27 expression and gender , age , histological type and depth of invasion ; differentiation, lymph node metastasis ( P < 0.05 ) . Expression in gastric ulcer ( 0.365 ± 0.018 ) and chronic atrophic gastritis ( 0.370 ± 0.023 ) than 2.TFF2 normal gastric mucosa ( 0.347 ± 0.032 ) , the difference was statistically significant ( P < 0.05 ) . Expression in gastric cancer ( 0.327 ± 0.020 ) lower than the first three , the difference was statistically significant ( P < 0.05 ) . TFF2 expression and gender, age, type of tissue and lymph node metastasis ; with the degree of differentiation , depth of invasion ( P < 0.05 ) . Conclusion : HSP27 and TFF2 protective factors of gastric mucosa and tumor development and metastatic spread and prognosis .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
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