Dissertation > Excellent graduate degree dissertation topics show

Expression and Significance of HSP27 and TFF2 in Human Gastric Cancer and Precancerous Disease

Author: RongFang
Tutor: HouHeng;LiLiFen
School: Shanxi Medical
Course: Department of Gastroenterology,
Keywords: Heat shock protein 27 Trefoil Factor II Immunohistochemistry
CLC: R735.2
Type: Master's thesis
Year: 2008
Downloads: 64
Quote: 0
Read: Download Dissertation


Objective: To investigate the heat shock protein 27 ( Heat shock protein27 , HSP27 ) , trefoil factor Ⅱ (Trefoilfactors2, TFF2) expression in gastric cancer and precancerous diseases and clinical significance . Methods: Immunohistochemistry (SABC) of 120 patients with pathologically confirmed 20 cases of normal gastric mucosa , gastric ulcer in 22 cases, 24 cases of chronic atrophic gastritis and gastric cancer 54 cases of HSP27 and TFF2 expression by image analysis software on HSP27 and TFF2 the average optical density were measured, and clinically relevant information for statistical analysis . Results : 1.HSP27 slower atrophic gastritis ( 0.305 ± 0.010 ) expression in normal gastric mucosa ( 0.291 ± 0.012 ) and gastric ulcer ( 0.302 ± 0.011 ) , chronic atrophic gastritis and normal gastric mucosa difference was statistically significance ( P < 0.05 ) . Expression of gastric cancer ( 0.314 ± 0.018 ) compared with the first three , the difference was statistically significant ( P < 0.05 ) . HSP27 expression and gender , age , histological type and depth of invasion ; differentiation, lymph node metastasis ( P < 0.05 ) . Expression in gastric ulcer ( 0.365 ± 0.018 ) and chronic atrophic gastritis ( 0.370 ± 0.023 ) than 2.TFF2 normal gastric mucosa ( 0.347 ± 0.032 ) , the difference was statistically significant ( P < 0.05 ) . Expression in gastric cancer ( 0.327 ± 0.020 ) lower than the first three , the difference was statistically significant ( P < 0.05 ) . TFF2 expression and gender, age, type of tissue and lymph node metastasis ; with the degree of differentiation , depth of invasion ( P < 0.05 ) . Conclusion : HSP27 and TFF2 protective factors of gastric mucosa and tumor development and metastatic spread and prognosis .

Related Dissertations

  1. Roles of MMP-7 and Lysozyme in the Pathogenesis of Ulcerative Colitis Induced by DSS in Balb/c Mice,S858.91
  2. The Study of Kisspeptin/GPR54 System on the Reproductive Regulation in the Hen’s Hypothalamus-Pituitary-Ovary Axis,S831
  3. Study on the Digestive Tube During the Embryonic Stage of Gushi Chicken,S831
  4. A Comparative Study of prawns, crabs, Spiroplasma disease immunohistochemistry and pathology,S945
  5. Expression of WW Domain Containing Oxidoreductase Gene in Cholangiocarcinoma and Its Effect on the Biological Behavior of Cancer Cell Line QBC939,R735.8
  6. Expressions of PRL-3 and p27 in Gastric Carcinoma and Their Clinical Significance,R735.2
  7. Expression of hnRNP A2/B1 and p21WAF1 Proteins in Lung Cancer and Their Clinical Significance,R734.2
  8. The Effects of RIP on the Immune Function of Renewal Rats Without Colostrums,S853.7
  9. Study on the Expression and Correlation of Metallothionein and Matrix Metalloproteinase-2 in Non-small Cell Lung Cancer,R734.2
  10. Expression and Their Significance of Apoptosis Regulatory Factors Survivin、XIAP and c-Jun、NF-κB in Epithelial Neoplasm of Ovary,R737.31
  11. Expression and Clinical Significance of Survivin and YAP in Cervical Carcinoma,R737.33
  12. Expression and Clinical Significance of PTEN and Caspase-7 in Gastric Cancer and Precancerous Lesion,R735.2
  13. Cloning and Expression Analysis of NCCRP-1 AND IL-10 Genes in Grass Carp (Ctenopharyngodon Idellus),S917.4
  14. Expression and Antibody Preparation of sglt1 from Cyprinus CarpioL.,S917.4
  15. The Effect of Hepatic Denervation on Liver Regeneration after Partially Hepatectomy in Rats,R363
  16. Expression and Correlation of Caspase-3 and Cx43 in Myocardial Infarction with Different Narrow Degree Coronary Artery,R542.22
  17. The Expression and Relationships of Bmi-1 and c-myc in Diffuse Large B-cell Lymphoma Tissues,R733.1
  18. Expression of Caspase-4 and Caspase-3 Gene Related Apoptosis in Pathological Changes of Sternocleidomastoid of Congenital Muscular Torticollis and Four Years Clinical Followed-up for Opereated Patients,R726.8
  19. The Feasibility of the Immunohistochemistry Classification to Predicting Prognosis in Breast Cancer,R737.9
  20. Expression Characteristics and Clinical Significance of RECK in Cervical Cancer,R737.33
  21. Study on Expression of Minichromosome Maintenance Proteins2、7 in Primary Squamous Cell Carcinoma and Cervical Intraepithelial Neoplasia and Its Significance,R737.33

CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gastric neoplasms
© 2012 www.DissertationTopic.Net  Mobile