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The Significance of COX-2 and Ki-67 Expressing in Hepatobiliary Calculus with Cholangiocarcinoma

Author: ChenChen
Tutor: WangQunWei
School: Central South University
Course: Surgery
Keywords: Bile duct stones Cholangiocarcinoma COX-2 Ki-67
CLC: R735.8
Type: Master's thesis
Year: 2010
Downloads: 12
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Abstract


Objective: To investigate the expression of COX-2, Ki-67 expression in the bile duct stones and in cholangiocarcinoma (HCWC) organization and its significance, studies of COX-2, Ki-67 and bile duct stones and bile duct cancer occurred, the development of the relationship, as provide the basis for clinical diagnosis and treatment of bile duct stones and cholangiocarcinoma. Methods: The medical records of 10 years from January 2000 to December 2009, complete clinical data collection of the Hunan Provincial People's Hospital of Hepatobiliary Surgery and surgical specimens. The experiment was divided into three groups: normal bile duct group (hepatic hemangioma resection specimens or liver trauma) 18 cases (A group), intrahepatic stones where the bile duct group of 55 cases (B group), bile duct stones and 44 cases of cholangiocarcinoma group (C group ), two groups (A, B) is set to the control group, the C group set to the experimental group. Application immunohistochemical method to detect the expression of COX-2 and Ki-67 situation, and test results analysis, observation of bile duct stones and bile duct cancer in COX-2, Ki-67 expression and various clinical correlation between pathological features. Results: 1.COX-2 expression in the group A, group B and group C positive rates were 5.56%, 32.72% and 70.45%, COX-2 expression was significantly higher than the normal bile duct stones and cholangiocarcinoma expression in the organization of the bile duct group bile duct and bile duct stones group, the difference was statistically significant (P lt; 0.05). COX-2 expression in the poorly differentiated group cholangiocarcinoma positive rate in well-differentiated group (P lt; 0.05); COX-2 expression in lymph node metastasis group was higher than without lymph node metastasis (P lt; 0.05); expression of COX 2 in extrahepatic tissues metastasis to the high rate of positive expression in extrahepatic tissues metastasis group (P lt; 0.05). COX-2 expression and bile duct stones and cholangiocarcinoma patient gender, regardless of the age, duration of disease, tumor size and tumor pathological type (P gt; 0.05). 2.Ki-67 expression in the group A, group B and group C positive rate 0,27.27% and 79.55%, respectively (P lt bile duct stones and cholangiocarcinoma positive expression rate was significantly higher bile duct tissue ; 0.05). Ki-67 expression in poorly differentiated group cholangiocarcinoma was higher than the well-differentiated group (P lt; 0.05); Ki-67 positive expression of lymph node metastasis group was higher than without metastasis (P lt; 0.05); Ki- 67 in extrahepatic tissues expression of metastasis was higher than without metastasis (P lt; 0.05). Regardless of the Ki-67 expression and bile duct stones and cholangiocarcinoma patient gender, age, duration of disease, tumor size and tumor pathological type (P gt; 0.05). Bile duct stones in the positive expression of COX-2 and cholangiocarcinoma, Ki-67 had higher expression, the positive rate was 90.32%, Spearman correlation analysis showed that bile duct stones and cholangiocarcinoma COX-2 expression of Ki-67 expression was positively correlated, r = 0.413, P = 0.005, statistically significant. Conclusion: 1.COX-2 high expression of bile duct stones and the occurrence of cholangiocarcinoma and progress is closely related; 2.Ki-67 high expression of bile duct stones and cholangiocarcinoma occur and progress is closely related; 3. Hepatobiliary duct stones and cholangiocarcinoma, COX-2 and Ki-67 expression was positively correlated.

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Gallbladder, bile duct cancer
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