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Expression and Clinical Significance of Mia2 and Vegf in Primary Hepatocellular Carcinoma

Author: YangShuai
Tutor: YangShaoQi
School: Ningxia Medical University
Course: Internal Medicine
Keywords: Hepatocellular carcinoma Melanoma inhibitory protein 2 Vascular endothelial growth factor Immunohistochemistry
CLC: R735.7
Type: Master's thesis
Year: 2010
Downloads: 7
Quote: 0
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Abstract


Purpose ( 1 ) detection of melanoma inhibitory protein (melanoma inhibitory activity , MIA2 ) and vascular endothelial growth factor (vascular endothlial growth factor, VEGF) expression in hepatocellular carcinoma and analyze its relationship with clinical pathological features . (2 ) to explore the relationship the MIA2 VEGF expression in HCC . Ningxia Medical University Hospital surgical resection archive of hepatocellular carcinoma (HCC) specimens collected in 2004-2008 in 36 cases, 29 cases of cancer tissue (cirrhosis) . Using immunohistochemistry UltraSensitiveT SP method hepatocellular carcinoma and adjacent organization the MIA2 and VEGF expression and clinical significance . Results in HCC and paraneoplastic organizations in 1. MIA2 in expression rate was 41.7 % ( 15 / 36 ) , 93.1% (27 / 29 ) , the difference was statistically significant ( X to 2 = 18.586 , P lt ; 0 . 05) , MIA2 liver cancer TNM stage, pathological grade and tumor metastasis (P lt; 0.05); 2. VEGF in HCC and paraneoplastic organizations expression rate was 77.8% ( 28 / 36 ) , 34.5 % ( 10 / 29 ) , the difference was statistically significance ( X to 2 = 12 398 , P lt; 0 , 05) , VEGF and tumor metastasis related (P lt; 0.05); 3. HCC tissues , MIA2 VEGF expression was negatively correlated (r = -0.497, P lt; 0.05). Showed low expression the conclusion MIA2 in HCC tissues and liver cancer TNM staging , pathological grade and tumor metastasis prompted MIA2 low expression of liver cancer cell proliferation and metastasis ; VEGF was highly expressed in HCC tissue and tumor metastasis the related ; expression of MIA2 and VEGF was negatively related to lowering may lead to increased expression of VEGF prompt MIA2 expression , thereby promoting liver cancer cell invasion and metastasis .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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