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Expression of Adiponectin and Nuclear Factor Kappa B and Their Significances in Colorectal Carcinoma

Author: MeiYaoLing
Tutor: XiongZhiFan
School: Huazhong University of Science and Technology
Course: Internal medicine Diseases of the Digestive
Keywords: Colorectal cancer Adiponectin NF-κBp65 Immunohistochemistry
CLC: R735.3
Type: Master's thesis
Year: 2010
Downloads: 23
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Abstract


Objective: To research adiponectin and nuclear transcription factor -kB expression in colorectal cancer , and its relationship with clinicopathological parameters , to investigate adiponectin and NF-kB in colorectal carcinogenesis , progression and metastasis of relations with role. Methods: The immunohistochemical method detected 42 cases of colorectal carcinoma , 20 colorectal adenomas and 42 cases of colorectal normal mucosa control tissue of adiponectin and of NF-kBp65 protein expression and localization of its positive image analysis software The expression results for semi-quantitative determination and analysis of their correlation . Results : colorectal cancer group adiponectin in small amounts in the tumor cell membrane and cytoplasm expression positive cells yellowish , scattered or spotty distribution , the group of normal colorectal adenoma group adiponectin was brown tawny uniform expression cellular membrane and cytoplasm of the duct of the gland in the large intestine tissue , adiponectin positive expression rates of colorectal cancer group and the relative expression were significantly lower than the adenoma and normal mucosa [ 40.5% , 75% , 85.7% ; ( 15.35 ± 3.81 ) , ( 38.71 ± 6.80) , ( 43.03 ± 4.89 ) , P lt; 0.05] and reduced with the degree of differentiation of colorectal cancer , lymph node metastasis , TNM staging progress down ; colorectal carcinoma NF- kBp65 protein positive expression was tawny brown located in the cytoplasm and nucleus of tumor cells in the positive expression in the adenoma group specimens and normal control group , but the stain is lighter , NF-kBp65 protein in colorectal carcinoma The positive expression rate and relative expression were significantly higher than the adenoma and normal mucosa [ 78.6 % , 50 % , 16.7 % ; ( 34.43 ± 2.36 ) , ( 27.15 ± 6.11 ) , ( 15.70 ± 2.36 ) , P lt ; 0.05 its expression to reduce the degree of differentiation with colorectal cancer , lymph node metastasis , and TNM staging progress higher ; adiponectin protein expression in colorectal cancer tissue between intensity and of NF-kBp65 protein expression intensity was negatively correlated (r = -0.881 , P lt; 0.01). Conclusion: colorectal cancer tissue adiponectin low expression of , NF - kBp65 high expression of adiponectin may play an important role in the incidence of colorectal cancer development , this effect may be mainly achieved by inhibiting the pathway of NF-kBp65 ; adiponectin factors is expected to become one of the important means of monitoring and prevention of colorectal cancer .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Intestinal neoplasms
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