Dissertation > Excellent graduate degree dissertation topics show

The Role of Complement 3 in the Pathogenesis of MPTP Induced Degeneration of DA Neurons and Potential Neuroprotection of Low Dose Whole Body γ-irradiation Against MPTP-induced Dopaminergic Toxicity in C57 Mice

Author: LiangYaJie
Tutor: SuBingYin
School: Third Military Medical University
Course: Neurobiology
Keywords: complement 3 Parkinson’s disease MPTP inflammation irradiation neuroprotection glial response knock out mouse
CLC: R392
Type: Master's thesis
Year: 2006
Downloads: 49
Quote: 0
Read: Download Dissertation

Abstract


Parkinson’s disease is characterized by the progressive loss of dopamine (DA) in the caudate nucleus, putamen, and substantia nigra upon the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc), resulting in cardinal motor symptoms such as tremor at rest, bradikinesia, muscular rigidity, stooped posture, and instability[1].The evidence for a chronic inflammatory reaction in the brain is particularly strong in Alzheimer’s disease (AD) where it has been extensively studied, but there is also a considerable literature suggesting that a local immune reaction occurs in affected regions of the brain in Parkinson’s disease (PD). The large number of recent reviews on the subject bears witness to the growing realization of the possible importance of this inflammatory response to PD progression[2]. The role of immune mechanisms in neurodegenerative diseases such as PD is an important area of investigation. Death of, or injury to, neurons leads to activation of glia and production of many pro-inflammatory cytokines and molecules[3].The complement system plays a key role in immune reactions and can kill host tissue directly by activation of membrane attack complex (MAC), or indirectly, through activation of macrophages that produce abundant levels of oxygen radicals and other toxic products. In PD, components of complement have been demonstrated in Lewy bodies, indicating activation of the classic complement pathway[4] [5]. Moreover, serum from patients with PD has been shown to be toxic to mesencephalic neurons in culture, and this toxicity is mediated by complement activation[6]. However, so far, there is still no in vivo studies demonstrating whether C3 plays a role in the pathogenesis of PD or in any animal models of PD.Recent studies demonstrated that low dose whole body irradiation is able to confer

Related Dissertations

  1. Studies on the Quality of Phisio-Chemical and Fresh Keeping Technologies of Post-Harvest in Volvariella Volvacea,S646.13
  2. Study of Intracerebral Transplantation of Umbilical Cord Blood Mesenchymal Stem Cells in a 6-Hydropamine Rat Model of Pakinson’s Disease,R742.5
  3. The Study on the Creep Resistance Property of Ultra-High Molecular Weight Polyethylene Fiber,TQ342.61
  4. The Effect and Mechanism of p38MAPK Inhibitor CBS3830 on Intimal Hyperplasia in Autogenous Vein Grafts of Diabetic Rats,R587.1
  5. The Related Study of Breast-conserving Surgery Plus Postoperative Tangential Irradiation,R737.9
  6. Studies on the Physiology and Biochemistry Characteristics and Fresh Keeping Technology of Post-Harvest in Pleurotus Eryngii,S646
  7. A Study of Cognition Function in Patients with Parkinson Disease,R742.5
  8. Influences of Different Health Status on the Clinical Laboratory Paramaters and Their Correlations with the HLA-DQB1,R346
  9. The Experimental Research of RNAi Technology Inhibiting Respiratory Syncytial Virus,R725.6
  10. Effect of Single and Double Mutations of Yeast H3K79L、H4K20L on the Function of ELP3 and Expression of SSA3,Q75
  11. Effect on Quality of Chilled Meat by Irradiation and Hawthorn Flavonoids Extract,TS251.51
  12. A Research on the Correlation between Uyghur Classification of Hilit and Immune Globulin , Complement, Serum C-peptide, Glycosylated Serum Protein,R29
  13. The Function of Fuantang Treating POI in Mice Model and the Mechanism Related with Mast Cell,R285.5
  14. Correlative Study on Plasma Level of Resistin in Patients with Coronary Atherosclerosis Disease,R541.4
  15. Effects of Blockade of IL-17 in Already Established Asthma of BALB/c Mice,R562.25
  16. The Function and Mechanism of Endoplasmic Reticulum Stress Pre-treatment on the Improvement of Renal Tolerance Toward Ischemia-reperfusion Injury,R692.5
  17. The Roles of Spinal Cord Glia in Bee Venom-induced Nociception and Inflammation in Concious Rats,R741
  18. The Effect of Berberine Hydrochloride on the Levels of Serum CRP and Complement C3, C4 in Patients with Acute Cerebral Infarction,R743.3
  19. The Correlation Analysis of Individualized Treatment and Disease Progression of Parkinson Disease,R742.5
  20. Studies of High Refractive Index Materials Prepared by Nano ZrO2 and TiO2 Hybrid Silicone Epoxy Resin,TB383.1
  21. Low-dose Methotrexate Suppresses Liver Inflammation Via Downregulating iNOS Expression of Macrophages,R363

CLC: > Medicine, health > Basic Medical > Medical Immunology
© 2012 www.DissertationTopic.Net  Mobile