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The Expression and Significance of IGF-2 and VEGF in Pterygium

Author: JiangHaiJing
Tutor: LuJie
School: Yanbian University
Course: Ophthalmology
Keywords: pterygium insulin-like growth factor-2 vascular endothelial growth factor immunohistochemistry
CLC: R779.6
Type: Master's thesis
Year: 2011
Downloads: 17
Quote: 0
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Abstract


Objective:The objective is to provide the theory basis for pathological mechanism, premedicant and prevent the recurrence of Pterygium through evaluate the expression level and relationship of IGF-2, VEGF in pterygium.Methods:52 cases patients with pterygium and strabismus were selected, all the patients were surgeried in yanbian university hospital from 2009.11 to 2010.10,28. All the cases were excluded other diseases of eye before surgery. All the cases were invaded into two groups.Experiment group:42 cases of pterygium, Age from38 to 65 and all the cases were with unilateral eye diseases(male:19, female:23). According to the the degree of local congestion and hypertrophy all patients were also divided into two groups: (1)Static group consisting of 17 patients; (2)Progressive group consisting of 25 patients.Control group:10 cases of patients with strabismus were selected as control group, Age from32 to 58(male:6, female:4).Evaluating the expression level of IGF-2 and VEGF in the two groups by immunohistochemistry.Results:1. The positive expression rate of IGF-2 in static group, progressive group and control group was 80.0%,41.2%vand 0.0% respectively, There were significant differences between the pterygium group and static group, control group respectively (P<0.05); There was no differences between the static group and control group in pterygium (P>0.05).2. The positive expression rate of VEGF in static group, progressive group and control group was 92.0%,52.9%vand30.0% respectively, There were significant differences between the pterygium group and static group, control group respectively (P<0.05); There was no differences between the static group and control group in pterygium (P>0.05). 3. The correlation of the positive express between IGF-2 and VEGF was analyzed by Spearman rank correlation method. The results showed that there was significantly positive correlation between IGF-2 and VEGF (r=0.378, P<0.05)Conclusion:1. The expression of IGF-2 and VEGF were higher than control group in the progressive and static stage of pterygium;2. IGF-2 and VEGF may contribute to the occurrence and development of pterygium;3. IGF-2 and VEGF in pterygium may have synergistic on pathogenesis.

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