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The Expression of Maspin and Caspase-3、MVD and Their Relation in the Hepatocellular Carcinoma

Author: ZhangJun
Tutor: QinXiHu
School: Suzhou University
Course: General Surgery
Keywords: Hepatocellular carcinoma Maspin Caspase-3 MVD Immunohistochemistry
CLC: R735.7
Type: Master's thesis
Year: 2010
Downloads: 27
Quote: 0
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Abstract


Objective: To study human hepatocellular carcinoma (hepatocellular carcinoma, HCC) in breast serine protease inhibition of the expression of the gene (mammary serpin, Maspin) , and hepatocellular carcinoma clinical and pathological features of contact , at the same time to analyze the cells wither death protease aspartate -specific cysteine ??protease -3 ( about aspartate - specific cysteine ??protease - 3 , caspase -3 ) and microvessel density (microvessel density, MVD) , aimed to explore of Maspin with hepatocellular carcinoma biological school behavior relationship , as well as in the development of hepatocellular carcinoma and its possible mechanisms . Method: using immunohistochemical methods (immunohistochemistry, IHC) were used to detect the expression of Maspin and Caspase-3, CD34 ( marker MVD) in 50 patients with hepatocellular carcinoma tissue and cancerous liver tissues . Results: HCC tissues of Maspin with the expression of Caspase-3 were lower than neighboring noncancerous liver tissue . Maspin Caspase-3 expression and liver cancer cell differentiation , the presence or absence of extrahepatic metastasis-associated lower liver cancer cell differentiation , extrahepatic metastasis , the expression of Maspin and Caspase-3 expression is lower , a positive correlation between the two . The MVD in HCC tissues than the neighboring noncancerous liver tissue, liver cancer cell differentiation lower extrahepatic metastasis , MVD is higher . Maspin expression was negatively correlated with MVD . Conclusion : Maspin possibly through the regulation of the apoptosis protease activity and inhibits angiogenesis inhibiting the development of hepatocellular carcinoma invasion and metastasis .

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CLC: > Medicine, health > Oncology > Gastrointestinal Cancer > Liver tumors
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