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Objective: dermal thickness and type I collagen observed by animal experiments changes in the role of Fomentation medicine \Methods: modeling Yamamoto scleroderma, 60 BALB / c mice were randomly divided into two groups, a group of 10 blank group, a model group 50 were shaved off the back of the same part of the Central District coat area of ??1.5 × 1.5cm size. Model group with 4 1/2 injection needle in the back of mice the central coat zone hypodermic bleomycin phosphate buffer solution, the concentration of 200μg/ml, 0.1ml / views, the blank group was injected with phosphate buffer 0.1ml / 1 / day. Both groups were continuous injection of 5 weeks. Fomentation medicine \10%, 20%, 40% medicine paste. Model group, 50 mice were randomly divided into a small concentration group in concentration group, large group concentration, model group, the control group treated with 10%, n = 10, corresponding to lesions in the back at 20%, 40% The fomentation drug that paste, model group without medication, western medicine group with heparin sodium ointment, 1 times / day, continuous January. Above medication is 1 times / day, continuous January. Medication after the end of the day before fasting, but water the next day were sacrificed by spinal dislocation, to take back the skin tissue fixed in 10% formalin solution. Take skin tissue dehydration, embedded in paraffin, HE staining, mouse dermal thickness analysis software. Type Ⅰ collagen expression using immunohistochemical techniques to detect the mouse skin tissue, and immunohistochemical analysis through software index. By observation before and after administration of the fomentation drug scleroderma a mouse model of skin lesions at the general morphology and changes in dermal thickness and content changes of the organ fibrosis material the main component of the extracellular matrix (collagen type I), a clear \the fomentation drug \Results: leather thickness: blank group and between each two groups analyzed between groups P gt; 0.05, not statistically significant, and no significant changes in dermal thickness. Average gray value of type I collagen: two analysis between groups, the control group and the rest of the group differences, P lt; 0.05; model group and low concentrations were not significantly different, P gt; 0.05; model group and concentrations, high concentrations of group differences, P lt; 0.05; concentration group and high concentration group difference that a high concentration of group therapy better than concentration in group P gt; 0.05. Conclusion: fomentation medicine \Fomentation medicine \
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