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The Effects of 17β-estradiol on the GLUT1’s Expression of Neonatal HIBD Rat

Author: HeYueQiu
Tutor: LiZuoRu
School: Sichuan University
Course: Pediatrics
Keywords: Estrogen Glucose transporter (GLUT1) Hypoxic-ischemic damage (HIBD) Immunohistochemistry Image analysis
CLC: R722.1
Type: Master's thesis
Year: 2004
Downloads: 27
Quote: 0
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Abstract


Hypoxic ischemic encephalopathy pathogenesis and energy depletion are closely related . Energy metabolism of the brain tissue , mainly by the oxidation of glucose to provide energy . The glucose utilization in the nerve cells can only rely on the cell membrane glucose transporter protein carrier . Recent studies that estrogen has a protective effect of neurons . But whether the protective effect of estrogen and related to the metabolism of glucose , little research . In this study, in the establishment of HIBD ( Hypoxic ischemic brain damage ) model based on the determination of glucose transporter protein 1 (glucose trnsporterl, GLUT1) changes by immunohistochemistry and image analysis to understand HIE (Hypoxia-ischemic encephalopathy) after changes in glucose metabolism and the protective effect of estrogen in energy metabolism . Studied as subjects, 7 -day-old SD rats 72 sham group , the control group , female dose group , male dose group were randomly divided into four groups . Each group is divided into immediate , 0 hours , 6 hours , 12 hours, 1 day, 3 days and 7 days of six periods . The Rice method produced HIBD model , the observed protective effect of estrogen on the brain tissue . Observed using immunohistochemistry and image analysis of semi-quantitative determination of the different the HIBD animal brain tissue area , time, and under conditions of different interventions GLUT1 in the impact, and to explore the role of estrogen .

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CLC: > Medicine, health > Pediatrics > Newborns, premature children disease > Neonatal disease
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