Dissertation > Excellent graduate degree dissertation topics show

The Relationship Study between ANP Gene and Essential Hypertension in Xinjiang Kazakhs

Author: ZhangYanMin
Tutor: LiNanFang
School: Xinjiang Medical University
Course: Department of Cardiology
Keywords: Essential hypertension Kazakhs ANP gene polymorphism Haplotype
CLC: R544.1
Type: PhD thesis
Year: 2006
Downloads: 155
Quote: 0
Read: Download Dissertation


Objective: To investigate the relationship between ANP gene T2238C, G1837A single nucleotide polymorphism (SNP), gene haplotype and essential hypertension in Xinjiang Kazakhs. Methods: 543 Xinjiang Kazakhs were recruited in our study. They were divided into 314 hypertensives (EH group) whose SBP>140mmHg and/or DBP> 90mmHg and 229 normotensives (NT group) whose BP<140/90mmHg. We measured their ANP gene T2238C, G1837A polymorphism by.PCR-RFLP method and tested the association of the polymorphism and heplotype with hypertension. Results: 1) We detected three kinds of genotype and two kinds of allele of ANP gene T2238C polymorphism. The frequencies of three kinds of genotype TT, TC, CC were 0.87, 0.11, 0.02 in hypertensive patients and 0.91, 0.08, 0.01 in controls respectively. The frequencies of two kinds of allele T and C were 0.93, 0.07 in hypertensives and 0.95, 0.05 in controls respectively. We also detected three kinds of genotype and two kinds of allele of G1837A polymorphism. The frequencies of genotype GG, GA and AA were 0.79, 0.20, 0.01 in hypertensives and 0.83, 0.16, 0.01 in controls respectively. The frequencies of G and A allele were 0.89, 0.11 in hypertensives and 0.91, 0.09 in controls respectively. 2) Both of genotype and allele frequencies of T2238C and G1837A had no significant differences between two groups (x~2 =2.013, P=0.36 and x~2 =1.022, P=0.312; x~2 =2.249, P=0.13 and x~2 =0.583, P=0.445 respectively). 3) We did not find association of 2238C allele with

Related Dissertations

  1. CYP2C19 Gene Polymorphism in Patients with Ischemic Cerebrovascular,R743
  2. Polymorphisms in the Promoter Region of Swine BMP7 Gene and Their Association with Reproductive Traits,S828
  3. Studies on Polymorphisms on Exon and Intron of BMP7 Gene and Their Associations with Reproductive Traits in Pigs,S828
  4. Cloning, Expression and Polymorphism Analysis of BMP4 Gene in Hu Sheep,S826
  5. Dendrobium candidum chloroplast microsatellite development and application of interspecific,S567.239
  6. Study on Genetic Variation and Its Effects and Expression of CFL2 Gene in Chickens,S831
  7. Study on the mRNA Expression Level and the Polymorphism of Follicle-Stimulating Hormone Receptor Gene in Taihu Pig’s Ovary,S828
  8. Epidemiological Investigation of Brucellosis in Livestock and Molecule Typing of Brucella Based on Single Nucleotide Polymorphism (SNP) Analysis,S855.12
  9. Polymorphisms of Y-STRs in Uygur and Kazak Ethnic in Xinjiang,R394
  10. The Relationship of Polymorphisms of Methionine Synthase Reductase(MTRR) Gene and Plasma Homocysteine Levels with Myocardial Infarction,R542.22
  11. Promoter Activity Analysis of Cytochrome P450 Gene CYP9A17v2 from Helicoverpa Armigera (H(?)bner),S435.622
  12. Study on the Physiological Differentiation and Genetic Diversity of Exserohilum Turcicum in Northeastern China,S435.131
  13. Clinical Study on Relationship Among Syndrome Differentiation Clssified in Tcm,ambulatory Blood Pressure Monitoring and Transcranial Doppler in Essential Hypertension,R259
  14. The Phenomenon That Antibodies Were Activated by Non-corresponding Antigen in Immune Response and the Correlations with H2-Eb Polymorphism,R392
  15. Heterogeneity and Meta Analysis of the Essential Hypertension Risk Assessments,R544.1
  16. Association of Single Nucleotide Polymorphisms in SCN5A and minK Gene with Atrial Fibrillation,R541.75
  17. Association of Interleukin-6 Gene Polymorphisms with Susceptibility to Coronary Heart Disease in Asian Populations: a Meta-analysis,R541.4
  18. Effects of Telmisartan on hs-CRP and HMW-adiponectinin Patients with Essential Hypertension,R544.1
  19. Study of the Expression of Toll-like Receptor 2, 4mRNA and Polymorphisms of Patients with Leprosy,R755
  20. MDR1 and CYP3A gene polymorphisms on digoxin plasma concentrations of,R96
  21. PPARa gene V227A polymorphism with early -onset type 2 diabetes Correlation,R587.1

CLC: > Medicine, health > Internal Medicine > Heart, blood vessels ( circulatory ) disease > Abnormal blood pressure > Hypertension
© 2012 www.DissertationTopic.Net  Mobile