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Gold Nanoparticles Modified Electrode and Its Application

Author: WeiXiaoZuo
Tutor: YeBaoXian
School: Zhengzhou University
Course: Analytical Chemistry
Keywords: Gold nanoparticles Self-assembly Serotonin Guanine Adenine
CLC: O646.54
Type: Master's thesis
Year: 2010
Downloads: 225
Quote: 0
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Abstract


Chemically modified electrode as electrochemical and electrical frontiers of analytical chemistry since the 1970s has been ongoing research. Has been widely used in life sciences, environmental science, analytical science, materials science and many other aspects. Mediator modified electrode surface can accelerate the test substance redox electron transfer speeds to achieve electro-catalytic reactions. Because nanomaterials have a lot of small particle size and specificity, gold nanoparticles due to its good biocompatibility and superior catalytic performance has been widespread concern in recent years become one of nanomaterials. In this paper, a modified gold nanoparticles modified electrode material preparation and make the following three aspects: 1. Using electrochemical methods layer self-assembly of gold nanoparticles gold nanoparticles / L-cysteine ??/ glassy carbon electrode (GNP / LC / GCE), and serotonin (5-HT) for separation and determination to investigate the sweep speed, etc. on the response of 5-HT and 5-HT were calculated gold nanoparticles modified electrode in the electrode kinetic parameters. Studies show that the electrode pair of 5-HT significantly catalytic oxidation in 6 × 10-8-6 × 10-6mol / L range of 5-HT oxidation peak current and concentration have a good linear relationship. The detection limit was 2 × 10-8mol / L. Ascorbic acid (AA) of folic acid (FA) epinephrine (EP) at the same time there is no interference on the determination of human serum samples of 5-HT levels were measured, the average recovery was 104.67%, and the relative standard deviation was 2.49%. (2) study the guanine gold nanoparticles modified electrode in the electrochemical behavior, investigated the impact of the scan rate and calculate the relevant electrode kinetic parameters. Compared with the glassy carbon electrode, gold nanoparticles modified electrode significantly improves the guanine oxidation peak current, making the measurement sensitivity is greatly improved. Accumulation potential and time on the experimental conditions were optimized in the best conditions in the determination of guanine oxidation peak current and the concentration of the linear range is wider, 9 × 10-8 ~ 2.9 × 10-5mol / L, the lowest detection limit of 7 × 10-8mol / L. 100 times Na, K, Cl-, SO42, and so the concentration of uric acid, ascorbic acid did not interfere with the determination. Human serum samples were determined guanine, the average recovery was 104.92%, and the relative standard deviation was 2.74%. 3 pairs of adenine gold nanoparticles modified electrode in electrochemical behavior were investigated and related electrode kinetic parameters were calculated. Adenine on Au modified electrode has good electrochemical response, the experimental conditions were optimized to determine the concentration of adenine oxidation peak current and the linear range was 9 × 10-8 ~ 3 × 10-6mol / L, the detection limit of 7 × 10-8mol / L. 100 times Na, K, Cl-, SO42-, 10 times the concentration of uric acid such as guanine and ascorbic acid did not interfere with the determination. The electrode can achieve a good separation of guanine and adenine. Human serum samples were determined guanine, the average recovery was 101.28%, and the relative standard deviation was 1.74%.

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CLC: > Mathematical sciences and chemical > Chemistry > Physical Chemistry ( theoretical chemistry ),chemical physics > Electrochemical,electrolytic,magnetic,chemical > Electrolysis and Electrode role > Electrode process
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