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Study on Immunity Function in Neonates with Hypoxic-ischemic Encephalopathy

Author: GuoHuiMei
Tutor: HuangJianPing
School: Dali University
Course: Pediatrics
Keywords: Hypoxic-ischemic encephalopathy Newborn Cell-mediated immunity Humoral immunity
CLC: R722.1
Type: Master's thesis
Year: 2010
Downloads: 27
Quote: 0
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Abstract


[Objective] hypoxic-ischemic encephalopathy (Hypoxic ischemic encephalopathy, HIE) neonatal peripheral blood T lymphocyte subsets and serum immunoglobulin changes both the relationship between the comprehensive analysis of cellular and humoral immunity in newborn child characteristics to provide a theoretical basis for the pathogenesis and immunotherapy of HIE HIE incidence. Materials and Methods] 30 different with HIE HIE group. Including 14 cases of mild, moderate and severe 16 cases; 13 males and 17 females. The normal newborns born in the same period 18 as normal control group. Including 11 males and 7 females. The two groups are 37-42 weeks gestational age, birth weight from 2500 to 4000g. HIE group were taken within 24 hours of birth peripheral blood 2ml potassium ethylenediamine tetraacetate (EDTA-K2) the vacuum blood and biological control. Normal control group, umbilical cord blood at birth 2ml in EDTA-K2 the vacuum blood and biological control are room temperature, 1 hour inspection. By flow cytometry of peripheral blood T cell subsets, turbidimetric immunoassay determination of serum immunoglobulins. SPSS16.0 statistical analysis software to process the results. Data are expressed as mean ± standard deviation (X ± S). HIE and normal groups were compared using two independent samples t-test; control group and HIE mild and moderate to severe HIE were compared using one-way ANOVA. [Results] 1.T cell subsets compare ① HIE group and normal control group comparison HIE group CD3, CD4 than the normal control group was significantly reduced, the difference was significant (P lt; 0.05); CD8, CD4 / CD8 no significant difference (P gt; 0.05). (2) the control group, mild HIE and severe HIE group comparison: CD3, CD4 expression between the the HIE mild and moderate to severe lower than the control group, the difference was significant (P lt; 0.05); CD8, CD4 / CD8 compared with the control group had no significant difference (P gt; 0.05). Comparison between the HIE mild and moderate to severe, CD3, CD4, CD8 and CD4 / CD8 There was no significant difference (P gt; 0.05) (2) serum immunoglobulin comparison: 1 HIE group and normal control group compared: the HIE group IgM low compared with normal control group, the difference was significant (P lt; 0.05); IgG and IgA was no significant difference (P GT ; 0.05). (2) the control group, mild HIE and severe HIE comparison: IgM is significantly lower than the control group in the expression of mild HIE with severe HIE, the difference was significant (P lt; 0.05). IgG, IgA compared with the control group There was no significant difference (P gt; 0.05); the HIE mild and moderate to severe HIE compared to IgG, IgA, and IgM was no significant difference (P gt; 0.05) [Conclusion] 1 neonatal hypoxic-ischemic encephalopathy cellular immunity is mainly manifested in the total T cells (CD3) and auxiliary / inducer T cells (CD4) reduced, but no significant reduction in both the magnitude and degree of HIE Relevance. Neonatal hypoxic-ischemic encephalopathy humoral immune mainly manifested in the reduction of serum immunoglobulin IgM, but with the range of the degree of HIE was no significant correlation.

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CLC: > Medicine, health > Pediatrics > Newborns, premature children disease > Neonatal disease
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